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DuoNeb was a U.S. trade name for a nebulized combination of albuterol sulfate and ipratropium bromide. The original trade product has been discontinued from U.S. marketing, while FDA-approved generic equivalents remain marketed. Current 3 mL unit-dose vials contain 0.5 mg ipratropium bromide and albuterol sulfate equivalent to 2.5 mg albuterol.
read more about duoneb ...Albuterol stimulates beta2 adrenergic receptors in bronchial smooth muscle and causes airway relaxation. Ipratropium blocks muscarinic receptors and reduces acetylcholine-mediated bronchoconstriction. Using both mechanisms produces bronchodilation in patients whose chronic obstructive pulmonary disease requires more than one bronchodilator.
The current inhalation medicine is indicated for bronchospasm associated with chronic obstructive pulmonary disease in patients who require more than one bronchodilator. It is inhaled through a jet nebulizer connected to an air compressor and is not injected or swallowed.
The recommended dose is one 3 mL vial by nebulization four times daily. Up to two additional 3 mL doses per day are permitted when needed. Higher dosing frequency or additional albuterol or ipratropium beyond these instructions has not been adequately studied under current labeling.
Serious concerns include paradoxical bronchospasm, cardiovascular effects, immediate hypersensitivity reactions, and harm from excessive sympathomimetic use. Albuterol can also lower serum potassium and raise blood glucose. The combination is contraindicated in patients with hypersensitivity to its ingredients or to atropine derivatives.
No. The original DuoNeb trade product is discontinued, while generic ipratropium and albuterol inhalation medicines remain marketed.
It contains 0.5 mg ipratropium bromide and albuterol sulfate equivalent to 2.5 mg albuterol.
The labeled regimen is one 3 mL vial four times daily, with up to two additional doses per day when needed.
It treats bronchospasm associated with COPD in patients requiring more than one bronchodilator.
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