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Dorzolamide hydrochloride eye drops are a prescription carbonic anhydrase inhibitor used to lower elevated intraocular pressure. Current 2% eye drops contain 20 mg of dorzolamide per mL. The medicine is indicated for patients with open-angle glaucoma or ocular hypertension.
read more about dorzolamide ...Dorzolamide inhibits carbonic anhydrase II in the ciliary processes of the eye. This decreases aqueous humor secretion by reducing bicarbonate formation and related sodium and fluid transport. Lower aqueous humor production reduces intraocular pressure, a major risk factor for optic nerve damage and glaucomatous visual field loss.
Dorzolamide eye drops treat elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Current labeling includes pediatric use based on clinical study data. The product is not recommended in severe kidney impairment with creatinine clearance below 30 mL per minute.
The recommended dose is one drop in the affected eye or eyes three times daily. Dorzolamide can be used with other topical eye medicines that lower intraocular pressure. When more than one topical ophthalmic medicine is used, doses are separated by at least five minutes.
Dorzolamide is a sulfonamide and is absorbed systemically despite topical eye use, so serious sulfonamide reactions are possible. Other concerns include bacterial keratitis from contaminated containers, corneal swelling in susceptible patients, and allergic eye reactions. Common reactions include burning, stinging, eye discomfort, and a bitter taste.
Dorzolamide lowers elevated eye pressure in open-angle glaucoma and ocular hypertension.
The recommended dose is one drop in the affected eye or eyes three times daily.
Yes. Different topical eye medicines are separated by at least five minutes.
No. Current labeling does not recommend it when creatinine clearance is below 30 mL per minute.
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DailyMed - DORZOLAMIDE HYDROCHLORIDE OPHTHALMIC solution. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e4e6a5a8-f7be-4424-83f2-d6bb4d57443e. Date Accessed September 25, 2026.
Dorzolamide. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a697049.html. Date Accessed September 25, 2026.
Dorzolamide. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Dorzolamide. Date Accessed September 25, 2026.
Dorzolamide Hydrochloride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Dorzolamide-Hydrochloride. Date Accessed September 25, 2026.