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Diprivan is a prescription intravenous anesthetic and sedative containing propofol at 10 mg per mL. It is used for induction of general anesthesia from age 3, maintenance of general anesthesia from age 2 months, monitored anesthesia care sedation in adults, sedation with regional anesthesia in adults, and intensive care sedation in intubated, mechanically ventilated adults.
read more about diprivan ...The exact mechanism of propofol is not fully defined. Its sedative and anesthetic effects are thought to involve positive modulation of inhibitory gamma-aminobutyric acid signaling through GABA-A receptors. Intravenous propofol acts rapidly, with anesthesia commonly beginning within about 40 seconds after a therapeutic induction dose.
Diprivan is administered for general anesthesia or sedation in monitored clinical settings. Pediatric labeling includes anesthesia induction from age 3 and anesthesia maintenance from age 2 months. It is not indicated for pediatric intensive care sedation. Adult uses also include monitored anesthesia care and sedation of intubated, mechanically ventilated intensive care patients.
Dosing is individualized according to age, medical condition, other medicines, and clinical response. Healthy adults younger than 65 commonly receive 2 mg to 2.5 mg per kg for anesthesia induction. Adult intensive care sedation commonly starts with a continuous infusion of 5 mcg per kg per minute, followed by gradual adjustments according to sedation response.
Diprivan can cause apnea, low blood pressure, slow heart rate, cardiac arrest, and serious hypersensitivity reactions. Prolonged or high-dose infusions have been associated with propofol infusion syndrome, which can involve metabolic acidosis, high potassium, rhabdomyolysis, kidney failure, and cardiac failure. Strict aseptic handling is required to reduce microbial contamination risk.
Diprivan contains propofol, an intravenous general anesthetic and sedative.
After an intravenous induction dose, anesthesia commonly begins within about 40 seconds.
No. Current labeling does not indicate Diprivan for intensive care sedation in pediatric patients.
Diprivan is administered by clinicians trained in general anesthesia or sedation with airway and resuscitation equipment immediately accessible.
DailyMed - DIPRIVAN (propofol) injection, emulsion. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e3105799-a4b6-f3f4-e6e2-b2b29bbdb538. Date Accessed September 25, 2026.
DIPRIVAN (propofol) Prescribing Information. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/019627Orig1s077lbl.pdf. Date Accessed September 25, 2026.
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