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Dipentum is a prescription aminosalicylate containing olsalazine sodium. It is approved to maintain remission of ulcerative colitis in adults who are intolerant of sulfasalazine. Each capsule contains 250 mg of olsalazine sodium. Kidney function is evaluated before treatment and periodically during therapy.
read more about dipentum ...Olsalazine reaches the colon and is converted by colonic bacteria into mesalamine, also called 5-aminosalicylic acid. Mesalamine then acts locally on colonic epithelial cells. Its precise mechanism is not fully defined, but its therapeutic activity appears to involve topical anti-inflammatory effects within the colon.
Dipentum is indicated for maintenance of ulcerative colitis remission in adults who are intolerant of sulfasalazine. It is not labeled to induce remission during an active ulcerative colitis flare. Current labeling does not establish safety and efficacy in pediatric patients.
The recommended dose is 500 mg by mouth twice daily, equal to two 250 mg capsules per dose. Patients are advised to drink adequate fluids during treatment to reduce the risk of kidney stone formation. Kidney function is assessed before therapy and periodically while treatment continues.
Serious concerns include kidney impairment, mesalamine-induced acute intolerance syndrome, hypersensitivity reactions, liver failure, severe skin reactions, photosensitivity, and kidney stones. Acute intolerance can resemble an ulcerative colitis flare with cramping, abdominal pain, bloody diarrhea, fever, headache, or rash. Hypersensitivity to salicylates or aminosalicylates is a contraindication.
Dipentum maintains remission of ulcerative colitis in adults who are intolerant of sulfasalazine.
The recommended dose is 500 mg twice daily.
No. Current labeling is for maintenance of remission rather than induction of remission.
Yes. Kidney function is checked before treatment and periodically during therapy.
DailyMed - DIPENTUM (olsalazine sodium) capsule, gelatin coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8512d0c6-db4e-4673-b3b4-28975c18413f. Date Accessed September 25, 2026.
Mesalamine. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK547995/. Date Accessed September 25, 2026.
Olsalazine. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601088.html. Date Accessed September 25, 2026.
Olsalazine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/22419. Date Accessed September 25, 2026.
Olsalazine Sodium. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Olsalazine-Sodium. Date Accessed September 25, 2026.