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Diflucan is a prescription triazole antifungal medicine containing fluconazole. Current oral forms include tablets and powder for oral suspension. Labeled uses include vaginal candidiasis, oropharyngeal and esophageal candidiasis, cryptococcal meningitis, and prevention of candidiasis in selected bone marrow transplant patients.
read more about diflucan ...Fluconazole selectively inhibits fungal lanosterol 14-alpha-demethylase, a cytochrome P450 enzyme needed for ergosterol production. Loss of normal membrane sterols and accumulation of abnormal sterol compounds disrupt fungal cell membrane function and contribute to fluconazole's antifungal activity.
Diflucan treats vaginal candidiasis, oropharyngeal candidiasis, esophageal candidiasis, and cryptococcal meningitis. Clinical labeling also describes activity in selected Candida urinary tract, peritoneal, and systemic infections. It is also used to reduce candidiasis in bone marrow transplant patients receiving cytotoxic chemotherapy or radiation therapy.
Vaginal candidiasis uses a single 150 mg oral dose. Oropharyngeal candidiasis uses 200 mg on day 1 followed by 100 mg once daily for at least two weeks. Esophageal candidiasis starts the same way but continues for at least three weeks and for at least two weeks after symptoms resolve. Kidney impairment can require dose reduction.
Serious risks include liver injury, severe skin reactions, anaphylaxis, QT prolongation, torsade de pointes, and major drug interactions. Fluconazole inhibits several cytochrome P450 enzymes and can raise concentrations of interacting medicines. Pregnancy-related risks differ by dose and treatment duration, so reproductive status is considered before therapy.
Diflucan contains fluconazole, a triazole antifungal medicine.
The recommended adult dose is a single 150 mg oral dose.
Yes. Fluconazole exposure is not meaningfully changed by food.
Yes. Reduced kidney function can require lower dosing for multi-dose treatment regimens.
DailyMed - DIFLUCAN (fluconazole tablets) (fluconazole for oral suspension). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f694c617-3383-416c-91b6-b94fda371204. Date Accessed September 25, 2026.
DIFLUCAN (fluconazole). Pfizer. https://www.pfizer.com/products/product-detail/diflucan. Date Accessed September 25, 2026.
Fluconazole. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a690002.html. Date Accessed September 25, 2026.
Fluconazole. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Fluconazole. Date Accessed September 25, 2026.
Fluconazole. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK537158/. Date Accessed September 25, 2026.