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Diacomit is a prescription antiseizure medicine containing stiripentol. It is approved for seizures associated with Dravet syndrome in patients taking clobazam who are age 6 months and older and weigh at least 7 kg. It comes as 250 mg and 500 mg capsules and powder packets for oral suspension.
read more about diacomit ...The exact anticonvulsant mechanism of stiripentol in humans is unknown. Proposed actions include direct effects involving GABA-A receptors and indirect effects from inhibition of cytochrome P450 enzymes, which increases blood concentrations of clobazam and its active metabolite.
Diacomit treats seizures associated with Dravet syndrome in patients taking clobazam who are at least 6 months old and weigh at least 7 kg. Current labeling states that clinical data do not establish Diacomit as monotherapy for Dravet syndrome.
The recommended total dose is 50 mg per kg daily, divided into two or three oral doses according to age and body weight. The maximum is 3000 mg daily. Capsules are swallowed whole with water during a meal. Powder is mixed with water and taken immediately during a meal.
Diacomit can cause sleepiness, decreased appetite, weight loss, neutropenia, thrombocytopenia, and suicidal thoughts or behavior. Blood counts are checked before treatment and every six months. Abrupt withdrawal can increase seizure frequency or trigger status epilepticus. The powder contains phenylalanine, which matters for patients with phenylketonuria.
Diacomit treats seizures associated with Dravet syndrome in eligible patients who are taking clobazam.
Current labeling includes patients age 6 months and older who weigh at least 7 kg.
The recommended total dose is 50 mg per kg daily in two or three divided doses.
No. Gradual withdrawal is recommended to reduce the risk of increased seizures or status epilepticus.
DailyMed - DIACOMIT (stiripentol) capsule and powder, for suspension. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=58304ba8-9779-4658-811e-94ffe08c3f16. Date Accessed September 24, 2026.
DIACOMIT (stiripentol) Prescribing Information. https://www.diacomit.com/prescribing-information/. Date Accessed September 24, 2026.
FDA Label - DIACOMIT (stiripentol). https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/206709s006lbl.pdf. Date Accessed September 24, 2026.
Stiripentol. MedlinePlus. https://medlineplus.gov/druginfo/meds/a618069.html. Date Accessed September 24, 2026.
Stiripentol. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Estiripentol. Date Accessed September 24, 2026.