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Dexamethasone is a prescription synthetic glucocorticoid corticosteroid used for inflammatory, allergic, endocrine, rheumatic, gastrointestinal, blood, respiratory, neurologic, eye, kidney, and selected cancer-related conditions. Oral tablets come in several strengths. Dosing varies widely by condition and is adjusted according to clinical response.
read more about dexamethasone ...Dexamethasone binds intracellular glucocorticoid receptors and changes gene transcription involved in inflammatory and immune responses. It has strong glucocorticoid activity with very little sodium-retaining activity compared with hydrocortisone at equivalent anti-inflammatory doses.
Current oral labeling includes severe allergic disorders, selected skin diseases, endocrine disorders, rheumatic diseases, acute exacerbations of multiple sclerosis, cerebral edema, inflammatory bowel disease, respiratory disorders, blood disorders, nephrotic syndrome, selected eye inflammation, and palliative treatment of leukemias and lymphomas.
Oral dosing is individualized according to the disease and treatment response. Current tablet labeling lists an initial adult range of 0.75 mg to 9 mg daily. After improvement, the dose is reduced gradually to the lowest amount that maintains the needed clinical response. Long-term therapy is generally tapered rather than stopped abruptly.
Dexamethasone can suppress adrenal function and increase susceptibility to infection. Other concerns include high blood glucose, fluid and electrolyte changes, osteoporosis, muscle weakness, gastrointestinal ulcers or bleeding, mood or psychiatric changes, cataracts, glaucoma, impaired wound healing, and growth suppression in children. Systemic fungal infection is a contraindication.
Yes. Dexamethasone is a synthetic glucocorticoid corticosteroid with strong anti-inflammatory activity.
Current tablet labeling lists an initial adult range of 0.75 mg to 9 mg daily, depending on the condition.
Yes. Systemic corticosteroid treatment suppresses immune activity and can increase susceptibility to infection.
No. After long-term therapy, the dose is generally reduced gradually rather than stopped abruptly.
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