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Detrol is a prescription medicine containing tolterodine tartrate, a muscarinic receptor antagonist. It treats overactive bladder in adults with urge urinary incontinence, urgency, and urinary frequency. Immediate-release tablets come in 1 mg and 2 mg strengths and are taken twice daily.
read more about detrol ...Tolterodine competitively blocks muscarinic receptors involved in bladder contraction. Its active 5-hydroxymethyl metabolite has similar antimuscarinic activity and contributes to the treatment effect. Reduced muscarinic signaling lowers detrusor pressure and reduces involuntary bladder contractions associated with overactive bladder symptoms.
Detrol tablets are approved for adults with overactive bladder accompanied by urge urinary incontinence, urgency, and frequency. Current labeling does not establish a pediatric indication. Treatment requires caution in patients with bladder outflow obstruction, reduced gastrointestinal motility, treated narrow-angle glaucoma, myasthenia gravis, or known QT prolongation.
The recommended starting dose is 2 mg twice daily. The dose can be reduced to 1 mg twice daily according to response and tolerability. Patients with significantly reduced kidney or liver function, or those taking potent CYP3A4 inhibitors, use 1 mg twice daily. Tablets can be taken with or without food.
Serious hypersensitivity, including anaphylaxis and angioedema, has occurred with tolterodine. Urinary retention, gastric retention, and uncontrolled narrow-angle glaucoma are contraindications. Other concerns include dizziness, sleepiness, blurred vision, constipation, dry mouth, reduced gastrointestinal motility, and QT prolongation in susceptible patients or at higher exposure.
Detrol treats adult overactive bladder with urgency, frequency, and urge urinary incontinence.
The recommended starting dose is 2 mg twice daily.
Yes. Dry mouth is a common antimuscarinic reaction with tolterodine.
Detrol is contraindicated with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, or specified hypersensitivity.
DailyMed - DETROL (tolterodine tartrate) tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=41eb00d2-64e3-4ec9-8732-4bfc81b04180. Date Accessed September 24, 2026.
DETROL and DETROL LA (tolterodine tartrate) Prescribing Information. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020771s019,021228s012lbl.pdf. Date Accessed September 24, 2026.
Tolterodine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a699026.html. Date Accessed September 24, 2026.
Tolterodine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Tolterodina. Date Accessed September 24, 2026.
Tolterodine. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557858/. Date Accessed September 24, 2026.