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Clodan is a prescription shampoo containing clobetasol propionate 0.05%, a super-high potency topical corticosteroid. It is indicated for moderate to severe scalp psoriasis in adults age 18 and older. The shampoo is applied only to affected areas of a dry scalp and is used for a limited treatment period.
read more about clodan ...Clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive activity. Its exact anti-inflammatory mechanism is unclear. Topical corticosteroids are thought to induce proteins that reduce production of inflammatory mediators derived from arachidonic acid, including prostaglandins and leukotrienes.
Clodan is indicated for adults with moderate to severe scalp psoriasis. Use in patients younger than 18 is not recommended due observed rates of hypothalamic-pituitary-adrenal axis suppression with clobetasol shampoo. Clodan is for scalp use and is not used on the face, groin, or underarms.
A thin film of Clodan is applied once daily to affected areas of a dry scalp and left in place for 15 minutes. Water is then added, and the hair and scalp are lathered and rinsed thoroughly. Treatment is limited to four consecutive weeks, with a weekly maximum of 50 mL.
Clodan can suppress the hypothalamic-pituitary-adrenal axis and can cause Cushing syndrome, high blood glucose, or unmask latent diabetes through systemic corticosteroid absorption. Local reactions include burning, itching, swelling, folliculitis, acne, dry skin, irritation, skin thinning, hair loss, hives, and visible small blood vessels.
Clodan treats moderate to severe scalp psoriasis in adults age 18 and older.
Clodan shampoo is applied once daily to affected areas of a dry scalp.
The shampoo stays on the scalp for 15 minutes before lathering and rinsing.
Current labeling limits treatment to four consecutive weeks and no more than 50 mL per week.
Clinical Pharmacology and Biopharmaceutics Review - CLOBEX Shampoo 0.05%. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/21-644_clobex_biopharmr.pdf. Date Accessed September 22, 2026.
Clobetasol Propionate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Clobetasol-propionate. Date Accessed September 22, 2026.
Clobetasol Topical. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a686008.html. Date Accessed September 22, 2026.
DailyMed - CLOBETASOL PROPIONATE shampoo. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=72c90da7-5f6a-4b8d-875d-f07ceeec295e. Date Accessed September 22, 2026.
DailyMed - CLODAN (clobetasol propionate) shampoo. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b5d32546-65dc-4b0c-826e-ddbc2a50b152. Date Accessed September 22, 2026.