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Celebrex is a prescription nonsteroidal anti-inflammatory drug containing celecoxib. It is approved for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis in patients age 2 and older, ankylosing spondylitis, acute pain in adults, and primary dysmenorrhea. Capsules come in 50 mg, 100 mg, 200 mg, and 400 mg strengths.
read more about celebrex ...Celecoxib inhibits prostaglandin synthesis primarily through cyclooxygenase-2 inhibition. Prostaglandins contribute to pain, inflammation, and fever by sensitizing nerves and participating in inflammatory signaling. Reducing prostaglandin production gives celecoxib its analgesic, anti-inflammatory, and antipyretic activity.
Celebrex treats signs and symptoms of osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis from age 2, and ankylosing spondylitis. It is also used for acute pain in adults and primary dysmenorrhea. Dose selection depends on the condition, age, body weight in pediatric arthritis, liver function, and CYP2C9 metabolism.
Osteoarthritis uses 200 mg once daily or 100 mg twice daily. Rheumatoid arthritis uses 100 mg to 200 mg twice daily. Ankylosing spondylitis starts with 200 mg daily. Acute pain and primary dysmenorrhea use 400 mg initially, followed by 200 mg later on the first day when needed, then 200 mg twice daily when needed.
Celebrex carries a boxed warning for serious cardiovascular thrombotic events and serious gastrointestinal bleeding, ulceration, or perforation. Other concerns include liver injury, high blood pressure, heart failure, kidney toxicity, high potassium, anaphylaxis, severe skin reactions, and fetal toxicity. Use during coronary artery bypass graft surgery is contraindicated.
Yes. Celebrex contains celecoxib, a nonsteroidal anti-inflammatory drug that primarily inhibits COX-2.
Celebrex treats several arthritis conditions, adult acute pain, and primary dysmenorrhea under current labeling.
Yes. The boxed warning covers serious cardiovascular thrombotic events and serious gastrointestinal bleeding, ulceration, and perforation.
No. Celecoxib is contraindicated in the setting of coronary artery bypass graft surgery.
CELEBREX (celecoxib) Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/020998s058lbl.pdf. Date Accessed September 21, 2026.
Celecoxib. MedlinePlus. https://medlineplus.gov/druginfo/meds/a699022.html. Date Accessed September 21, 2026.
Celecoxib. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/2662. Date Accessed September 21, 2026.
Celecoxib. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK535359/. Date Accessed September 21, 2026.
DailyMed - CELEBREX (celecoxib) capsule. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d6675e4-5859-4be2-8037-a20ce9f707aa. Date Accessed September 21, 2026.