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What Is Brown-McLean Syndrome?

Brown-McLean syndrome is a rare corneal condition that causes peripheral corneal swelling, usually appearing years after cataract surgery. The swelling, or edema, typically begins at the lower edge of the cornea and gradually spreads around its outer rim, leaving the central cornea clear. Most patients do not experience pain or significant vision loss, but some may notice halos, mild irritation, or blurred vision.

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What Is Brown-McLean Syndrome?

Brown-McLean syndrome is a rare corneal condition that causes peripheral corneal swelling, usually appearing years after cataract surgery. The swelling, or edema, typically begins at the lower edge of the cornea and gradually spreads around its outer rim, leaving the central cornea clear. Most patients do not experience pain or significant vision loss, but some may notice halos, mild irritation, or blurred vision.

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What Causes Brown-McLean Syndrome?

The exact cause is not fully understood, but it is thought to be related to changes in the corneal endothelium following surgery. Mechanical trauma from the intraocular lens or long-term contact between the iris and cornea may contribute. Reduced endothelial cell count after cataract removal can also make the cornea more vulnerable to fluid buildup.

What Are the Symptoms of Brown-McLean Syndrome?

Early stages often cause no symptoms. As swelling develops, patients may experience mild discomfort, glare, or cloudy vision in dim lighting. Some people notice a golden-brown ring around the corneal edge due to pigment deposition. Vision usually remains good because the central cornea is not affected.

How Is Brown-McLean Syndrome Diagnosed?

Diagnosis usually includes:

  • A slit-lamp examination to detect corneal edema and pigment rings
  • Specular microscopy to evaluate endothelial cell density
  • Corneal pachymetry to measure thickness changes
  • Review of surgical history to confirm prior cataract or intraocular procedures

How Is Brown-McLean Syndrome Treated?

Most cases do not require aggressive treatment. Lubricating eye drops or hypertonic saline solutions help reduce corneal swelling and discomfort. Regular monitoring by an eye specialist ensures the condition remains stable. In rare cases with central involvement or discomfort, surgical options such as corneal transplantation may be considered.

When to Get Checked

If you experience new corneal discomfort or peripheral swelling after cataract surgery, arrange an evaluation. This condition often appears years after surgery and needs monitoring. Early care helps prevent further corneal changes. Report any changes in vision or increased sensitivity. Ongoing exams support corneal health.

Frequently Asked Questions

Why does Brown-McLean swelling stay at the corneal edge?

The condition mainly affects peripheral endothelial function, so fluid builds at the rim first. Central endothelial cells often stay healthier, keeping the center clearer. Pigment changes at the edge can appear alongside swelling. The pattern can stay stable for years in many cases.

Can contact lens wear affect symptoms?

Contact lenses can add friction and reduce oxygen at the corneal surface, which can worsen irritation in some people. Lens fit and material also matter for comfort. A doctor can suggest a safer wearing plan or an alternate lens type if needed. Stop lens wear and seek evaluation if redness or pain increases.

Which drops are commonly used for comfort?

Lubricating drops can ease dryness and scratchy sensations. Hypertonic saline drops or ointment can help pull fluid out of the cornea in some cases. Use any medicated drop only under clinician guidance. If drops sting badly or symptoms worsen, contact the clinic.

When is surgery considered for Brown?McLean syndrome?

Surgery is uncommon because the center of the cornea often stays clear and vision can remain stable. It can be considered if swelling spreads centrally, pain becomes persistent, or vision drops. The surgeon will weigh benefits against risks based on corneal measurements. Regular follow-up helps catch changes early so decisions are not rushed.

References

1. Brown McLean Syndrome. EyeWiki. https://eyewiki.org/Brown_McLean_Syndrome. Accessed January 16, 2026.

2. Brown-McLean syndrome. PubMed Central (PMC). https://pmc.ncbi.nlm.nih.gov/articles/PMC3822196/. Accessed January 16, 2026.

3. Clinical Findings in Brown-McLean Syndrome. American Journal of Ophthalmology (ScienceDirect). https://www.sciencedirect.com/science/article/pii/S0002939414736396. Accessed January 16, 2026.

4. Brown–McLean syndrome: the role of iridodonesis. OPTH (DovePress / Taylor & Francis PDF). https://www.tandfonline.com/doi/pdf/10.2147/OPTH.S96507. Accessed January 16, 2026.

5. Atypical clinical presentations of Brown–McLean syndrome. Eye (Nature). https://www.nature.com/articles/6702244. Accessed January 16, 2026.

6. Brown-Mclean syndrome revisited. Indian Journal of Ophthalmology. https://journals.lww.com/ijo/fulltext/2020/68010/brown_mclean_syndrome_revisited.52.aspx. Accessed January 16, 2026.