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Banzel is a prescription antiseizure medicine containing rufinamide. It is approved as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in adults and children age 1 and older. Banzel comes as 200 mg and 400 mg film-coated tablets and a 40 mg per mL oral suspension. Treatment is taken with food in two divided daily doses.
read more about banzel ...The exact antiseizure mechanism of rufinamide is unknown. Laboratory studies indicate that rufinamide modulates sodium channel activity and prolongs the inactive state of these channels. This action slows recovery of sodium channels and limits sustained repetitive firing of neurons, which is thought to contribute to seizure control.
Banzel is approved as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in patients age 1 and older. It is added to an existing antiseizure regimen rather than used as the sole labeled therapy for this syndrome. Familial short QT syndrome is a contraindication.
Children start at about 10 mg per kg daily in two divided doses, with increases of about 10 mg per kg every other day up to 45 mg per kg daily and no more than 3200 mg daily. Adults start at 400 to 800 mg daily in two divided doses and increase every other day up to 3200 mg daily.
Serious risks include suicidal thoughts or behavior, central nervous system effects, QT interval shortening, DRESS, and low white blood cell counts. Headache, dizziness, fatigue, sleepiness, nausea, and vomiting are reported adverse reactions. Banzel is withdrawn gradually to reduce the risk of increased seizures, seizure worsening, or status epilepticus.
Banzel is used with other antiseizure medicines for seizures associated with Lennox-Gastaut syndrome in patients age 1 and older.
Yes. Banzel tablets and oral suspension are taken with food in two divided daily doses.
Yes. Current labeling states that Banzel tablets can be taken whole, split in half, or crushed.
People with familial short QT syndrome should not take Banzel.
BANZEL (rufinamide) Prescribing Information. https://us.eisai.com/-/media/Files/BanzelPatient/BanzelPI.pdf. Date Accessed September 15, 2026.
DailyMed - BANZEL (rufinamide) tablet, film coated and suspension. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a3fa925-1abd-458a-bd57-4ae780a1ef2d. Date Accessed September 15, 2026.
New Pediatric Labeling Information Database - BANZEL (rufinamide). https://www.accessdata.fda.gov/scripts/sda/sdDetailNavigation.cfm?id=14F7A847BCDF0979E053564DA8C00FF5&rownum=290&sd=labelingdatabase. Date Accessed September 15, 2026.
Rufinamide. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a609001.html. Date Accessed September 15, 2026.
Rufinamide. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557595/. Date Accessed September 15, 2026.