Provide a valuable resource to your clients or customers by linking to this resource page. Just place the following link on your website.
Aldactone is a prescription medicine containing spironolactone, an aldosterone antagonist and potassium-sparing diuretic. It is approved for certain patients with heart failure, hypertension, edema associated with hepatic cirrhosis or nephrotic syndrome, and primary hyperaldosteronism. Aldactone tablets come in 25 mg, 50 mg, and 100 mg strengths. Dosing depends on the condition and clinical response.
read more about aldactone ...Spironolactone competes with aldosterone at receptor sites involved in sodium and potassium exchange in the distal renal tubule. Blocking aldosterone increases sodium and water excretion while reducing potassium loss. This action accounts for its diuretic and blood-pressure-lowering effects and its role in disorders where excess aldosterone or fluid retention contributes to the condition.
Aldactone is approved for New York Heart Association Class III to IV heart failure with reduced ejection fraction, add-on treatment of hypertension, selected edema associated with hepatic cirrhosis or nephrotic syndrome, and primary hyperaldosteronism. For primary hyperaldosteronism, it is used before surgery or as long-term treatment in patients who are not surgical candidates.
Aldactone dosing varies by indication. Heart failure treatment commonly starts at 25 mg once daily. Hypertension treatment starts at 25 to 100 mg daily in one or divided doses. Edema treatment commonly starts at 100 mg daily in a hospital setting. Primary hyperaldosteronism treatment before surgery uses higher individualized doses. Potassium and kidney function are checked during therapy.
The main safety concern is hyperkalemia, or high blood potassium, which can become dangerous. Aldactone can also cause low blood pressure, worsening kidney function, other electrolyte changes, and gynecomastia. It is contraindicated in people with hyperkalemia or Addison's disease and in those taking eplerenone. Potassium levels and renal function need regular clinical monitoring.
Yes. Aldactone contains spironolactone, an aldosterone antagonist with potassium-sparing diuretic activity.
Yes. Aldactone is approved as add-on treatment for hypertension and lowers blood pressure through aldosterone blockade and sodium excretion.
Yes. Hyperkalemia is a major safety concern, especially with kidney impairment or medicines and supplements that raise potassium.
Yes. It is approved for selected patients with Class III to IV heart failure and reduced ejection fraction.
ALDACTONE (spironolactone) Prescribing Information. https://www.pfizermedical.com/aldactone. Date Accessed September 11, 2026.
DailyMed - ALDACTONE (spironolactone) Tablet, Film Coated. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0fed2822-3a03-4b64-9857-c682fcd462bc. Date Accessed September 11, 2026.
FDALabel - Aldactone (spironolactone). https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/380181. Date Accessed September 11, 2026.
Spironolactone. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682627.html. Date Accessed September 11, 2026.
Spironolactone. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK554421/. Date Accessed September 11, 2026.