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Imdur was an extended-release isosorbide mononitrate product used to prevent angina pectoris caused by coronary artery disease. FDA lists the 30 mg, 60 mg, and 120 mg Imdur products as discontinued. Generic isosorbide mononitrate extended-release tablets remain available in the United States.
read more about what was imdur ...Isosorbide mononitrate is an organic nitrate that relaxes vascular smooth muscle. Nitrate activity increases cyclic guanosine monophosphate in smooth muscle, producing vasodilation. Venous dilation reduces cardiac preload and myocardial oxygen demand, which helps prevent angina.
Current generic extended-release tablets are indicated for prevention of angina pectoris caused by coronary artery disease. Their onset is not fast enough to stop an acute angina attack once it has started.
The recommended starting dose is 30 mg or 60 mg once daily in the morning. After several days, the dose can increase to 120 mg once daily. A 240 mg daily dose is used rarely. Extended-release tablets are swallowed with fluid and are not chewed or crushed.
Isosorbide mononitrate can cause severe low blood pressure, dizziness, headache, and fainting. Sildenafil can markedly increase the blood pressure lowering effect and cause severe hypotension. Methemoglobinemia has also occurred with organic nitrate exposure.
Imdur contained extended-release isosorbide mononitrate, an organic nitrate used to prevent angina.
No. FDA lists Imdur as discontinued, while generic isosorbide mononitrate extended-release tablets remain available.
The recommended starting dose is 30 mg or 60 mg once daily in the morning.
No. Its onset is not rapid enough to stop an acute anginal episode.
Approved Drug Products With Therapeutic Equivalence Evaluations 46th Edition. https://www.fda.gov/media/71474/download. Date Accessed October 2, 2026.
DailyMed - ISOSORBIDE MONONITRATE tablet, extended release. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a1e317a-7b05-4d30-9bbc-1d4ccd56ba3c. Date Accessed October 2, 2026.
Isosorbide - MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a682348.html. Date Accessed October 2, 2026.
Isosorbide - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557839/. Date Accessed October 2, 2026.
Isosorbide Mononitrate Extended-Release Tablets 30 mg, 60 mg, and 120 mg. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=897a0327-25d4-4769-bd6a-0e674264017f. Date Accessed October 2, 2026.