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Hydergine was a prescription ergoloid mesylates product used for symptomatic relief of certain forms of idiopathic decline in mental capacity in older adults. It contained a mixture of hydrogenated ergot alkaloid mesylates. Ergoloid mesylates and Hydergine products have been discontinued in the United States.
read more about what was hydergine ...The precise mechanism responsible for the mental effects of ergoloid mesylates was not established in the U.S. labeling. The labeling also stated that conclusive evidence did not establish a specific effect on cerebral arteriosclerosis or cerebrovascular insufficiency.
Historical labeling described use in some people older than 60 with signs and symptoms of an idiopathic decline in mental capacity after potentially reversible and treatable causes had been excluded. Hydergine was not indicated for acute or chronic psychosis.
The historical labeled dose was 1 mg three times daily. Symptomatic change was gradual, and the labeling stated that results could take three to four weeks to appear. This is historical dosing information and does not represent a current U.S. treatment recommendation.
Hydergine was contraindicated in patients with hypersensitivity to ergoloid mesylates and in patients with acute or chronic psychosis. Reported adverse effects included transient nausea and gastric disturbances. Clinical reassessment was needed since the symptoms targeted by treatment could arise from other neurologic, systemic, or psychiatric conditions.
Hydergine contained ergoloid mesylates, a mixture of hydrogenated ergot alkaloid salts.
No. Ergoloid mesylates and Hydergine products have been discontinued in the United States.
The labeled dose was 1 mg three times daily.
No. Acute or chronic psychosis was a contraindication under the historical U.S. labeling.
DailyMed - ERGOLOID MESYLATES tablet. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1344cf98-7d79-4ab4-9a63-2e632d9afbd4. Date Accessed October 1, 2026.
Ergoloid Mesylates. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682097.html. Date Accessed October 1, 2026.
Ergoloid Mesylates. MeSH Browser. https://meshb.nlm.nih.gov/record/ui?ui=D004877. Date Accessed October 1, 2026.
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