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Regular human insulin is a short-acting insulin used to improve glycemic control in adults and children with diabetes mellitus. Current U.S. products include U-100 regular insulin and concentrated U-500 regular insulin. U-500 is reserved for patients whose daily insulin requirement exceeds 200 units.
read more about regular human insulin ...Regular human insulin increases glucose uptake in skeletal muscle and fat and decreases glucose production in the liver. It also reduces lipolysis and proteolysis and increases protein synthesis. U-100 and U-500 contain human insulin but differ greatly in concentration and dosing instructions.
U-100 regular human insulin is used in adults and pediatric patients with diabetes mellitus and can be part of basal-bolus or other insulin regimens. U-500 is used in adults and children who require more than 200 units of insulin per day.
U-100 regular human insulin is injected subcutaneously about 30 minutes before a meal and can also be administered intravenously under medical supervision. U-500 is injected subcutaneously two or three times daily about 30 minutes before meals. All doses are individualized according to metabolic needs and blood glucose results.
Hypoglycemia can be life-threatening. Other concerns include hypokalemia, severe hypersensitivity, medication errors, lipodystrophy, localized cutaneous amyloidosis, and fluid retention or heart failure with thiazolidinediones. Confusion between U-100 and U-500 concentrations can cause severe overdose or inadequate dosing.
U-100 regular human insulin is a short-acting insulin used for meal-time and other insulin regimens.
It is injected subcutaneously about 30 minutes before a meal.
U-500 is intended for patients who require more than 200 units of insulin per day.
Yes. U-100 regular human insulin can be administered intravenously under medical supervision.
Human Insulin Injection: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a682611.html. Date Accessed October 5, 2026.
HUMULIN R (Insulin Human) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b519bd83-038c-4ec5-a231-a51ec5cc291f. Date Accessed October 5, 2026.
HUMULIN R U-500 (Insulin Human) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b60e8dd0-1d48-4dc9-87fd-e14675255e8c. Date Accessed October 5, 2026.
NOVOLIN R (Human Insulin) Prescribing Information. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aee7f1f3-612c-4027-8ce9-4fd1f41eed71. Date Accessed October 5, 2026.
Regular Insulin. https://www.ncbi.nlm.nih.gov/books/NBK553094/. Date Accessed October 5, 2026.