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What Is Qbrexza?

Qbrexza is a prescription topical medication containing glycopyrronium 2.4%, an anticholinergic agent. It is approved to treat primary axillary hyperhidrosis, a condition involving excessive underarm sweating, in adults and children aged nine years and older. Qbrexza is supplied as individually packaged, premoistened cloths for application to the underarms. It reduces sweat production by interfering with nerve signals that activate sweat glands. Qbrexza is not intended for use on the face, hands, or other body areas. Careful application is necessary because accidental exposure to the eyes can cause blurred vision and pupil dilation.

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What Is Qbrexza?

Qbrexza is a prescription topical medication containing glycopyrronium 2.4%, an anticholinergic agent. It is approved to treat primary axillary hyperhidrosis, a condition involving excessive underarm sweating, in adults and children aged nine years and older. Qbrexza is supplied as individually packaged, premoistened cloths for application to the underarms. It reduces sweat production by interfering with nerve signals that activate sweat glands. Qbrexza is not intended for use on the face, hands, or other body areas. Careful application is necessary because accidental exposure to the eyes can cause blurred vision and pupil dilation.

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How Does Qbrexza Work?

Qbrexza contains glycopyrronium, which blocks muscarinic acetylcholine receptors involved in stimulating sweat glands. Acetylcholine is a neurotransmitter that activates eccrine sweat glands through muscarinic signaling. By interfering with this activity, glycopyrronium reduces sweat production in the treated underarm areas. Although Qbrexza is applied to the skin, some medication can be absorbed into the bloodstream and cause anticholinergic effects elsewhere in the body. These effects can include dry mouth, reduced sweating outside the treated area, and blurred vision. Qbrexza controls excessive sweating but does not permanently cure hyperhidrosis.

What Condition Does Qbrexza Treat?

Qbrexza is approved for primary axillary hyperhidrosis in adults and pediatric patients aged nine years and older. Primary axillary hyperhidrosis causes excessive sweating in the underarms beyond what is needed for normal temperature regulation. The condition can occur even without heat or physical activity. Qbrexza provides a topical treatment option when excessive underarm sweating interferes with daily activities. It is not approved for generalized sweating or excessive sweating caused by an underlying medical disorder. Patients with glaucoma, myasthenia gravis, Sj?gren's syndrome, or certain gastrointestinal conditions should not use Qbrexza because its anticholinergic effects can worsen these conditions.

How Should Qbrexza Be Applied?

Qbrexza is applied once daily using one single-use cloth for both underarms. Apply it to clean, dry, intact skin by wiping across one entire underarm once, then using the same cloth to wipe the other underarm once. Do not apply more frequently than once every 24 hours or use the cloth on broken skin. Discard the used cloth immediately, keeping it away from children and others. Wash hands thoroughly with soap and water after application to prevent accidental transfer into the eyes. Avoid touching the eyes or inserting contact lenses with unwashed hands. Do not cover treated skin with occlusive dressings.

What Are the Side Effects and Warnings of Qbrexza?

Common adverse effects include dry mouth, blurred vision, dilated pupils, urinary hesitation, dry eyes, constipation, and skin irritation. Accidental contact with the eyes can cause temporary pupil dilation and blurred vision, sometimes affecting one eye. Serious anticholinergic effects can include urinary retention and impaired temperature regulation from reduced sweating. Qbrexza should not be used by patients with glaucoma or other listed contraindications. Patients should avoid overheating during hot weather or exercise and seek medical attention if sweating becomes inadequate. New blurred vision, eye pain, or difficulty urinating requires prompt assessment.

Common Questions About Qbrexza

Is Qbrexza used for excessive sweating?

Yes. Qbrexza is approved for primary axillary hyperhidrosis in adults and children aged nine years and older.

How often should Qbrexza be applied?

Use one Qbrexza cloth once daily to treat both underarms. The same cloth is used for each underarm and then discarded.

Can Qbrexza cause blurred vision?

Yes. Accidental eye exposure can cause pupil dilation and blurred vision. Wash hands with soap and water immediately after use and avoid touching the eyes.

Can contact lens wearers use Qbrexza?

Contact lens wearers should take particular care to wash their hands thoroughly after application before handling their lenses. Qbrexza must not come into contact with the eyes.

References

A 44-Week Open-Label Study Evaluating Safety and Efficacy of Topical Glycopyrronium Tosylate in Patients with Primary Axillary Hyperhidrosis. Dermatology and Therapy. https://pubmed.ncbi.nlm.nih.gov/31111409/. Date Accessed November 2, 2026.

DailyMed - QBREXZA (glycopyrronium) cloth. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5b372650-e56e-47a5-93e2-c0c292017059. Date Accessed November 2, 2026.

Glycopyrronium Topical. MedlinePlus. https://medlineplus.gov/druginfo/meds/a618046.html. Date Accessed November 2, 2026.

Qbrexza. Journey Medical Corporation. https://www.qbrexza.com/. Date Accessed November 2, 2026.

Topical Glycopyrronium Tosylate for the Treatment of Primary Axillary Hyperhidrosis: Results From the ATMOS-1 and ATMOS-2 Phase 3 Randomized Controlled Trials. Journal of the American Academy of Dermatology. https://pubmed.ncbi.nlm.nih.gov/?term=ATMOS-1+ATMOS-2+glycopyrronium+tosylate. Date Accessed November 2, 2026.