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What Is Oxtellar XR?

Oxtellar XR is a prescription extended-release antiseizure medication containing oxcarbazepine. It is approved to treat partial-onset seizures in adults and children aged six years and older. Its extended-release formulation is designed for once-daily administration, unlike immediate-release oxcarbazepine products commonly taken twice daily. Oxtellar XR helps reduce abnormal electrical activity associated with focal seizures. It can be used alone or alongside other antiseizure medications when prescribed. The medication is not a cure for epilepsy.

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What Is Oxtellar XR?

Oxtellar XR is a prescription extended-release antiseizure medication containing oxcarbazepine. It is approved to treat partial-onset seizures in adults and children aged six years and older. Its extended-release formulation is designed for once-daily administration, unlike immediate-release oxcarbazepine products commonly taken twice daily. Oxtellar XR helps reduce abnormal electrical activity associated with focal seizures. It can be used alone or alongside other antiseizure medications when prescribed. The medication is not a cure for epilepsy.

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How Does Oxtellar XR Work?

Oxtellar XR releases oxcarbazepine gradually after oral administration. The body converts oxcarbazepine into an active metabolite called MHD, which affects voltage-sensitive sodium channels in nerve cells. This helps stabilize overactive neuronal membranes and reduce repetitive electrical firing associated with focal seizures. The extended-release tablet changes how the medication enters the bloodstream but does not create a different active antiseizure mechanism. Its controlled-release design makes consistent once-daily administration possible.

Who Can Receive Oxtellar XR Treatment?

Oxtellar XR is approved for partial-onset seizures in patients aged six years and older. It can be prescribed as monotherapy or adjunctive treatment according to the patient's seizure history and clinical needs. A neurologist considers seizure frequency, other medications, kidney function, age, and body weight when selecting a dose. Patients switching from immediate-release oxcarbazepine require individual dose assessment because equivalent milligram doses can produce different medication exposure. Oxtellar XR is not intended for every type of seizure disorder.

How Should Oxtellar XR Be Taken?

Oxtellar XR is taken once daily on an empty stomach, at least one hour before or two hours after food. Tablets must be swallowed whole without cutting, crushing, or chewing. Adults commonly begin at 600 mg once daily, with increases at weekly intervals according to response and tolerability. The recommended adult maintenance range is 1,200 mg to 2,400 mg once daily. Pediatric doses depend on body weight, and kidney impairment can require dose adjustments. Do not stop treatment abruptly because seizures can worsen or become prolonged.

What Are the Side Effects and Warnings of Oxtellar XR?

Common adverse effects include dizziness, sleepiness, headache, nausea, double vision, and balance problems. Serious risks include low blood sodium, severe allergic reactions, serious skin reactions, and changes in mood or suicidal thoughts. Patients with previous allergic reactions to carbamazepine can have an increased risk of reacting to oxcarbazepine. Oxtellar XR can also reduce the effectiveness of certain hormonal contraceptives. Clinicians assess sodium levels when appropriate. Severe rash, facial swelling, confusion, or worsening seizures requires prompt medical evaluation.

Common Questions About Oxtellar XR

Is Oxtellar XR the same as oxcarbazepine?

Oxtellar XR contains oxcarbazepine in an extended-release formulation. It has a different dosing schedule from immediate-release oxcarbazepine.

How often is Oxtellar XR taken?

Oxtellar XR is taken once daily on an empty stomach, at least one hour before or two hours after a meal.

Can Oxtellar XR tablets be crushed?

No. Oxtellar XR tablets must be swallowed whole. Crushing, chewing, or cutting them can interfere with the extended-release formulation.

Can Oxtellar XR cause double vision?

Yes. Double vision and other visual disturbances are recognized adverse effects. Persistent or severe symptoms should be evaluated by a healthcare professional.

References

DailyMed - OXTELLAR XR (oxcarbazepine) extended-release tablet. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aa610e56-1d1d-11e1-8bc2-0800200c9a66. Date Accessed October 22, 2026.

Oxcarbazepine. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548414/. Date Accessed October 22, 2026.

Oxcarbazepine. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601245.html. Date Accessed October 22, 2026.

Oxcarbazepine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/oxcarbazepine. Date Accessed October 22, 2026.

Oxtellar XR. Supernus Pharmaceuticals. https://www.oxtellarxr.com/about-oxtellar-xr. Date Accessed October 22, 2026.