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What Is Opill?

Opill is an over-the-counter oral contraceptive containing norgestrel 0.075 mg, a synthetic progestin. It is used to prevent pregnancy without requiring a prescription in the United States. Opill does not contain estrogen and is taken once daily without breaks between packs. Its effectiveness depends on consistent dosing at the same time every day. Opill does not protect against HIV or other sexually transmitted infections and is not intended for emergency contraception.

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What Is Opill?

Opill is an over-the-counter oral contraceptive containing norgestrel 0.075 mg, a synthetic progestin. It is used to prevent pregnancy without requiring a prescription in the United States. Opill does not contain estrogen and is taken once daily without breaks between packs. Its effectiveness depends on consistent dosing at the same time every day. Opill does not protect against HIV or other sexually transmitted infections and is not intended for emergency contraception.

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How Does Opill Prevent Pregnancy?

Opill contains norgestrel, a progestin that changes conditions within the reproductive system to reduce the likelihood of pregnancy. It primarily thickens cervical mucus, making it more difficult for sperm to reach an egg. It also changes the uterine lining and can suppress ovulation in some cycles. Unlike combined oral contraceptives containing estrogen, traditional progestin-only pills do not consistently suppress ovulation in every cycle. Taking Opill at the same time daily is necessary for reliable contraceptive protection.

Who Can Use Opill for Birth Control?

Opill is intended for people who can become pregnant and want an estrogen-free oral contraceptive. It is available without a prescription but should not be used by anyone with current or previous breast cancer. People with unexplained vaginal bleeding, liver conditions, or medications that interfere with hormonal contraception should seek medical advice before use. Opill is not intended to treat menstrual disorders or other hormonal conditions. People who need protection from sexually transmitted infections should also use appropriate barrier methods.

How Should Opill Be Taken?

Take one Opill tablet orally at the same time every day, including during menstrual bleeding. Start the next pack immediately after finishing the previous pack without taking a break. Use backup contraception, such as condoms, during the first 48 hours after starting Opill. A tablet taken more than three hours late is considered late. Take it as soon as remembered, continue the regular schedule, and use backup contraception for the next 48 hours. Vomiting or severe diarrhea within four hours of a dose also requires following the label's backup contraception instructions.

What Are the Side Effects and Warnings of Opill?

Common side effects include irregular menstrual bleeding, spotting, nausea, breast tenderness, headache, and acne. Some users experience lighter periods or missed periods. Opill should not be used by people with current or previous breast cancer. Certain antiseizure medications and other enzyme-inducing drugs can reduce its contraceptive effectiveness. A positive pregnancy test, severe lower abdominal pain, or unusual persistent bleeding requires medical assessment. Opill does not prevent sexually transmitted infections, and missed or delayed doses increase pregnancy risk.

Common Questions About Opill

Is Opill available without a prescription?

Yes. Opill is an FDA-approved over-the-counter oral contraceptive containing norgestrel 0.075 mg.

Does Opill contain estrogen?

No. Opill contains only the progestin norgestrel and does not contain estrogen.

What happens when an Opill dose is more than three hours late?

Take the missed tablet as soon as remembered, continue the regular schedule, and use backup contraception for the next 48 hours.

Does Opill protect against sexually transmitted infections?

No. Opill prevents pregnancy but does not protect against HIV or other sexually transmitted infections. Condoms help reduce the risk of certain infections.

References

DailyMed - OPILL (norgestrel) tablet. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=69dfa2ac-6a7e-4587-929c-9acabd97973b. Date Accessed October 22, 2026.

FDA Approves First Nonprescription Daily Oral Contraceptive. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-first-nonprescription-daily-oral-contraceptive. Date Accessed October 22, 2026.

Norgestrel. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/16051930. Date Accessed October 22, 2026.

Opill (0.075mg Oral Norgestrel Tablet) Information. U.S. Food and Drug Administration. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/opill-0075mg-oral-norgestrel-tablet-information. Date Accessed October 22, 2026.

Progestin-Only (norgestrel) Oral Contraceptives. MedlinePlus. https://medlineplus.gov/druginfo/meds/a623039.html. Date Accessed October 22, 2026.