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What Is Ofev?

Ofev is a prescription medication containing nintedanib, an oral kinase inhibitor used to treat certain fibrotic interstitial lung diseases. It is approved for adults with idiopathic pulmonary fibrosis and chronic fibrosing interstitial lung diseases that have a progressive phenotype. Ofev is also approved to slow the rate of lung function decline in adults with systemic sclerosis-associated interstitial lung disease. It acts on signaling pathways involved in tissue scarring but does not cure pulmonary fibrosis.

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What Is Ofev?

Ofev is a prescription medication containing nintedanib, an oral kinase inhibitor used to treat certain fibrotic interstitial lung diseases. It is approved for adults with idiopathic pulmonary fibrosis and chronic fibrosing interstitial lung diseases that have a progressive phenotype. Ofev is also approved to slow the rate of lung function decline in adults with systemic sclerosis-associated interstitial lung disease. It acts on signaling pathways involved in tissue scarring but does not cure pulmonary fibrosis.

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How Does Ofev Work?

Ofev inhibits several tyrosine kinases involved in processes that contribute to lung fibrosis, including receptors associated with platelet-derived growth factor, fibroblast growth factor, and vascular endothelial growth factor. These signaling pathways participate in fibroblast activity and the development of scar tissue. By inhibiting them, nintedanib can slow the rate of decline in lung function in certain fibrotic lung diseases. It does not reverse existing lung scarring or immediately relieve shortness of breath.

What Lung Conditions Does Ofev Treat?

Ofev is approved for idiopathic pulmonary fibrosis, a condition characterized by progressive scarring of the lungs without a known cause. It is also used for chronic fibrosing interstitial lung diseases with a progressive phenotype, where fibrosis continues to worsen. Another indication is slowing lung function decline in adults with systemic sclerosis-associated interstitial lung disease. A pulmonary specialist evaluates lung imaging, pulmonary function testing, symptoms, and medical history before prescribing treatment.

How Should Ofev Be Taken?

The recommended Ofev dose for most adults is 150 mg orally twice daily, approximately 12 hours apart, with food. Patients with mild liver impairment generally receive 100 mg twice daily. Capsules should be swallowed whole and should not be crushed or chewed. Dose reduction or temporary interruption can be necessary for significant diarrhea or other adverse reactions. Clinicians assess liver function before treatment and monitor it during therapy. Patients should follow instructions for missed doses rather than doubling the next dose.

What Are the Side Effects and Warnings of Ofev?

Diarrhea is one of the most common adverse effects of Ofev. Other effects include nausea, vomiting, abdominal pain, reduced appetite, and weight loss. Serious risks include liver injury, bleeding, gastrointestinal perforation, arterial thromboembolic events, and harm to an unborn baby. Nintedanib can affect wound healing and requires special consideration around surgery. Patients should report persistent diarrhea, signs of dehydration, unusual bleeding, severe abdominal pain, or yellowing of the skin. Regular laboratory monitoring helps identify liver-related complications.

Common Questions About Ofev

Does Ofev cure pulmonary fibrosis?

No. Ofev can slow the rate of lung function decline in certain fibrotic lung diseases, but it does not cure the condition or reverse existing scar tissue.

How often is Ofev taken?

Ofev is generally taken twice daily, approximately 12 hours apart, with food. Some patients require a lower dose.

Why does Ofev cause diarrhea?

Diarrhea is a common adverse effect of nintedanib related to its effects on gastrointestinal signaling and function. Persistent symptoms require treatment advice and sometimes dose adjustment.

Can Ofev cause liver problems?

Yes. Ofev can increase liver enzymes and cause serious liver injury. Liver function testing is recommended before treatment and during therapy.

References

DailyMed - OFEV (nintedanib) capsule. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=da1c9f37-779e-4682-816f-93d0faa4cfc9. Date Accessed October 22, 2026.

Nintedanib. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548135/. Date Accessed October 22, 2026.

Nintedanib. MedlinePlus. https://medlineplus.gov/druginfo/meds/a615009.html. Date Accessed October 22, 2026.

Nintedanib. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/135423438. Date Accessed October 22, 2026.

Nintedanib. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK585049/. Date Accessed October 22, 2026.