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What Is Nexlizet?

Nexlizet is a prescription combination medication containing bempedoic acid and ezetimibe. It is used alongside diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia, including heterozygous familial hypercholesterolemia. Its two active ingredients lower cholesterol through different mechanisms. The bempedoic acid component also has an approved indication for reducing major cardiovascular events in certain adults who cannot take recommended statin therapy.

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What Is Nexlizet?

Nexlizet is a prescription combination medication containing bempedoic acid and ezetimibe. It is used alongside diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia, including heterozygous familial hypercholesterolemia. Its two active ingredients lower cholesterol through different mechanisms. The bempedoic acid component also has an approved indication for reducing major cardiovascular events in certain adults who cannot take recommended statin therapy.

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How Does Nexlizet Work?

Nexlizet combines two complementary cholesterol-lowering mechanisms. Bempedoic acid inhibits ATP-citrate lyase, reducing cholesterol production in the liver. Ezetimibe blocks the NPC1L1 transporter in the small intestine, decreasing cholesterol absorption from the digestive tract. Together, these actions lower the amount of LDL cholesterol circulating in the bloodstream. The combination is intended to produce a greater LDL-lowering effect than either component alone.

Who Can Benefit From Nexlizet?

Nexlizet is approved for adults with high LDL cholesterol, including those with heterozygous familial hypercholesterolemia. It can be prescribed when additional cholesterol reduction is appropriate alongside dietary changes and other indicated treatments. The bempedoic acid component has demonstrated cardiovascular risk reduction in certain adults unable to take recommended statin therapy. Clinicians consider LDL levels, cardiovascular history, gout risk, tendon conditions, and existing medications before prescribing Nexlizet.

How Should Nexlizet Be Taken?

Nexlizet is taken as one tablet once daily, with or without food. Each tablet contains 180 mg of bempedoic acid and 10 mg of ezetimibe. Swallow the tablet whole and follow the prescribed schedule. When used with bile acid sequestrants, Nexlizet should be taken at least two hours before or four hours after those medications. Cholesterol levels are monitored to evaluate treatment response, and additional dose adjustments to the fixed-dose combination are not available.

What Are the Side Effects and Warnings of Nexlizet?

Nexlizet can increase uric acid levels, potentially triggering gout, and has been associated with tendon injury or rupture. Other possible side effects include abdominal discomfort, diarrhea, muscle spasms, and elevated liver enzymes. Serious hypersensitivity reactions can also occur. Patients with previous tendon disorders require careful evaluation. Medication interactions include dose restrictions with certain statins and timing adjustments with bile acid sequestrants. Report sudden tendon pain, significant joint swelling, or allergic symptoms promptly.

Common Questions About Nexlizet

What is the difference between Nexlizet and Nexletol?

Nexletol contains bempedoic acid alone. Nexlizet combines bempedoic acid with ezetimibe to lower LDL cholesterol through two different mechanisms.

Is Nexlizet a statin medication?

No. Nexlizet contains an ATP-citrate lyase inhibitor and a cholesterol absorption inhibitor. It does not contain a statin.

How often is Nexlizet taken?

Nexlizet is taken once daily. Each tablet contains 180 mg of bempedoic acid and 10 mg of ezetimibe.

Can Nexlizet cause tendon problems?

Yes. Tendon injury and rupture are recognized risks associated with bempedoic acid. Sudden tendon pain or swelling should be assessed promptly.

References

Bempedoic Acid. MedlinePlus. https://medlineplus.gov/druginfo/meds/a620020.html. Date Accessed October 19, 2026.

Bempedoic Acid. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK594232/. Date Accessed October 19, 2026.

DailyMed - NEXLIZET (bempedoic acid and ezetimibe) tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3fa2108c-0300-47b8-9d34-f762af7c93c6. Date Accessed October 19, 2026.

Ezetimibe. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548095/. Date Accessed October 19, 2026.

Ezetimibe. MedlinePlus. https://medlineplus.gov/druginfo/meds/a603015.html. Date Accessed October 19, 2026.