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Mucinex is an over-the-counter medicine available in several formulations with different active ingredients. This page focuses on single-ingredient Mucinex extended-release tablets containing 600 mg of guaifenesin. Guaifenesin is an expectorant that helps loosen mucus and thin bronchial secretions, making coughs more productive.
read more about mucinex ...Guaifenesin increases the hydration of respiratory secretions and helps reduce mucus thickness. This makes mucus easier to move through the airways and expel by coughing. Mucinex relieves chest congestion symptoms but does not treat the underlying cause of an infection.
Single-ingredient Mucinex 600 mg extended-release tablets are labeled for adults and children age 12 and older with bothersome chest mucus. A doctor should assess persistent or chronic coughing associated with asthma, smoking, chronic bronchitis, or emphysema before use. This tablet formulation is not intended for children younger than 12.
Adults and children age 12 and older take one or two 600 mg extended-release tablets every 12 hours. The maximum is four tablets, equivalent to 2400 mg, in 24 hours. Tablets are swallowed whole with a full glass of water and are not crushed, chewed, or broken. Dosing for maximum-strength and combination Mucinex products differs.
Mucinex can cause nausea, vomiting, headache, or dizziness in some patients. Medical evaluation is needed when a cough lasts more than seven days, returns after improving, or occurs with fever, rash, or persistent headache. Patients with chronic cough or excessive mucus should seek medical advice before use. Taking more than the labeled dose increases the risk of adverse reactions.
Single-ingredient Mucinex 600 mg extended-release tablets contain guaifenesin, an expectorant.
It loosens mucus and thins bronchial secretions so coughing can clear them more easily.
Adults and children age 12 and older should not exceed four tablets, or 2400 mg, in 24 hours.
No. The extended-release tablets must be swallowed whole and should not be crushed, broken, or chewed.
DailyMed - MUCINEX (guaifenesin) tablet, extended release. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd379cdd-90ab-42e0-ad89-f50d3220f611. Date Accessed October 16, 2026.
Guaifenesin. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682494.html. Date Accessed October 16, 2026.
Guaifenesin. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Guaifenesin. Date Accessed October 16, 2026.
Guaifenesin Tablets. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/24710-guaifenesin-tablets. Date Accessed October 16, 2026.
Mucinex Extended-Release Bi-Layer Tablets. Mucinex. https://www.mucinex.com/products/mucinex-se-extended-release-bi-layer-tablets. Date Accessed October 16, 2026.