Provide a valuable resource to your clients or customers by linking to this resource page. Just place the following link on your website.
Metolazone is a prescription thiazide-like diuretic and antihypertensive medicine. Current tablets contain 2.5 mg, 5 mg, or 10 mg. It treats fluid retention associated with congestive heart failure or kidney disease and is used for hypertension. Different metolazone formulations can have different absorption characteristics and are not automatically interchangeable.
read more about metolazone ...Metolazone reduces sodium reabsorption in kidney tubules, increasing urinary excretion of sodium, chloride, and water. It also increases potassium loss. Removing excess fluid reduces swelling, while its diuretic and vascular effects contribute to lower blood pressure.
Metolazone is used in patients with edema from congestive heart failure or kidney disease, including nephrotic syndrome and reduced kidney function. It is also used alone or with other antihypertensive medicines for elevated blood pressure. Patients with anuria, hepatic coma or precoma, or hypersensitivity to metolazone must not receive it.
For the current conventional metolazone tablets, edema associated with heart failure or kidney disease usually starts at 5 mg to 20 mg once daily. Mild to moderate hypertension commonly uses 2.5 mg to 5 mg once daily. Doses are adjusted according to response, blood pressure, fluid status, kidney function, and electrolyte measurements. Conventional metolazone tablets are not substituted milligram for milligram with Mykrox-type formulations.
Metolazone can cause rapid or severe reductions in sodium and potassium, potentially leading to weakness, confusion, muscle cramps, or dangerous heart rhythm disturbances. Other serious concerns include dehydration, low blood pressure, kidney dysfunction, elevated uric acid, and increased blood glucose. Combining metolazone with other diuretics can intensify fluid and electrolyte losses.
Metolazone treats edema from heart failure or kidney disease and is also used for hypertension.
Conventional metolazone tablets commonly start at 5 mg to 20 mg once daily for edema.
The usual dose is 2.5 mg to 5 mg once daily with the conventional tablet formulation.
Yes. Metolazone can cause serious hypokalemia and hyponatremia, so electrolyte monitoring is part of treatment.
DailyMed - METOLAZONE tablet. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a8c38aa-362e-6bcc-e063-6294a90a1e05. Date Accessed October 14, 2026.
Metolazone. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682345.html. Date Accessed October 14, 2026.
Metolazone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Metolazone. Date Accessed October 14, 2026.
Metolazone. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK534203/. Date Accessed October 14, 2026.
Thiazide Diuretics. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548680/. Date Accessed October 14, 2026.