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Macrobid is a prescription nitrofurantoin antibiotic containing 100 mg of nitrofurantoin per capsule as monohydrate and macrocrystals. It is indicated for acute uncomplicated urinary tract infections, also called acute cystitis, caused by susceptible Escherichia coli or Staphylococcus saprophyticus. It is not indicated for kidney infection or perinephric abscess.
read more about macrobid ...Bacteria convert nitrofurantoin into reactive compounds that interfere with bacterial proteins, DNA, and other cellular processes. The medicine reaches concentrations in urine that kill susceptible bacteria responsible for certain bladder infections.
Macrobid is used in adults and adolescents older than 12 years with uncomplicated cystitis caused by susceptible bacteria. The current product label does not establish safety and efficacy below age 12. It is contraindicated in patients with significant renal impairment as defined in its label, at the end of pregnancy, and in patients with prior nitrofurantoin-related liver injury.
Adults and pediatric patients older than 12 take one 100 mg capsule by mouth every 12 hours for seven days under current Macrobid labeling. Capsules are taken with food to improve absorption and tolerability. The prescribed course is completed even when urinary symptoms improve earlier.
Serious concerns include acute or chronic pulmonary reactions, sometimes involving pulmonary fibrosis, severe liver injury, peripheral neuropathy that can become irreversible, and hemolytic anemia in people with glucose-6-phosphate dehydrogenase deficiency. Clostridioides difficile-associated diarrhea can also occur. Macrobid is contraindicated at 38 to 42 weeks of pregnancy, during labor or delivery, and in newborns younger than one month due to the risk of hemolytic anemia.
Macrobid treats uncomplicated bladder infections caused by susceptible Escherichia coli or Staphylococcus saprophyticus.
The current label directs one 100 mg capsule every 12 hours for seven days in adults and pediatric patients older than 12.
Yes. Taking Macrobid with food improves absorption and gastrointestinal tolerability.
No. Macrobid is not indicated for pyelonephritis or perinephric abscesses.
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Nitrofurantoin. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548318/. Date Accessed October 13, 2026.
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