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Lyrica is a prescription Schedule V medicine containing pregabalin. It is indicated for selected neuropathic pain conditions, fibromyalgia, and adjunctive treatment of partial-onset seizures in patients age 1 month and older. Current forms include capsules and an oral liquid.
read more about lyrica ...Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This changes neurotransmitter release and contributes to its effects on nerve pain and seizure activity. The complete mechanism responsible for clinical improvement is not established.
Lyrica is used in adults with neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, or fibromyalgia. It is also used with other antiseizure medicines for partial-onset seizures in adults and children age 1 month and older. Dosing in children depends on body weight and age.
Adult treatment commonly starts at a total of 150 mg daily in two or three divided doses. The maximum recommended daily dose is 300 mg for diabetic peripheral neuropathy, 450 mg for fibromyalgia, and 600 mg for selected other indications. Pediatric seizure dosing is weight-based. Reduced kidney function requires dose adjustment.
Serious concerns include angioedema, severe allergic reactions, suicidal thoughts or behavior, and life-threatening respiratory depression, particularly with opioids or underlying breathing disorders. Dizziness, sleepiness, swelling, weight gain, and impaired coordination can occur. Abrupt discontinuation can cause withdrawal symptoms and seizures, so treatment is tapered over at least one week.
Lyrica treats selected neuropathic pain conditions and fibromyalgia and is used as adjunctive treatment for partial-onset seizures.
Current labeling includes adjunctive treatment of partial-onset seizures from age 1 month.
Adult treatment commonly starts at 150 mg daily divided into two or three doses.
No. Current labeling recommends tapering over at least one week to reduce withdrawal symptoms and seizure risk.
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