Provide a valuable resource to your clients or customers by linking to this resource page. Just place the following link on your website.
Lybalvi is a prescription combination of olanzapine, an atypical antipsychotic, and samidorphan, an opioid antagonist. It treats schizophrenia in adults and bipolar I disorder in adults, including acute manic or mixed episodes and maintenance monotherapy. Each tablet contains 10 mg of samidorphan with 5 mg, 10 mg, 15 mg, or 20 mg of olanzapine.
read more about lybalvi ...Olanzapine acts on dopamine and serotonin receptors involved in psychotic and mood symptoms. Samidorphan blocks opioid receptors and has been associated with less weight gain than olanzapine alone in a controlled study. The exact mechanism responsible for the overall therapeutic effects is not established.
Lybalvi is used in adults with schizophrenia or bipolar I disorder. For bipolar I disorder, it can treat manic or mixed episodes alone or with lithium or valproate and can be used alone for maintenance treatment. Patients using opioids or experiencing acute opioid withdrawal must not receive Lybalvi.
For schizophrenia, treatment usually starts at 5 mg/10 mg or 10 mg/10 mg once daily. For acute bipolar I mania or mixed episodes, monotherapy starts at 10 mg/10 mg or 15 mg/10 mg daily. The maximum dose is 20 mg olanzapine with 10 mg samidorphan once daily. Tablets are taken with or without food and are not split or combined to make doses.
Lybalvi carries a boxed warning for increased mortality in older adults with dementia-related psychosis. Samidorphan can precipitate severe opioid withdrawal and increase the risk of fatal opioid overdose when patients attempt to overcome its opioid blockade. Other serious concerns include neuroleptic malignant syndrome, tardive dyskinesia, high blood glucose, weight gain, lipid abnormalities, orthostatic hypotension, and severe hypersensitivity reactions.
Lybalvi treats schizophrenia and bipolar I disorder in adults under the labeled treatment regimens.
Each tablet contains olanzapine and 10 mg of samidorphan.
No. Use in patients taking opioids or undergoing acute opioid withdrawal is contraindicated.
Yes. The boxed warning concerns increased mortality in older adults with dementia-related psychosis.
DailyMed - LYBALVI (olanzapine and samidorphan L-malate) tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=32ffddd1-4e2b-45d9-9b36-bb730167ec80. Date Accessed October 13, 2026.
LYBALVI (olanzapine and samidorphan) Prescribing Information. Alkermes. https://www.alkermesmedicalaffairs.com/pdf?file=https%3A%2F%2Fwww.alkermesmedicalaffairs.com%2Fproduct-information%2Flybalvi%2Fpdf-file%2Fprescribing-information. Date Accessed October 13, 2026.
Olanzapine and Samidorphan. MedlinePlus. https://medlineplus.gov/druginfo/meds/a621051.html. Date Accessed October 13, 2026.
Olanzapine; Samidorphan L-Malate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lybalvi. Date Accessed October 13, 2026.
Samidorphan. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/samidorphan. Date Accessed October 13, 2026.