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Liothyronine sodium is a prescription synthetic form of triiodothyronine, also called T3. Current labeling includes thyroid hormone replacement for congenital or acquired primary, secondary, or tertiary hypothyroidism, thyroid-stimulating hormone suppression in selected well-differentiated thyroid cancer, and use as a diagnostic agent in thyroid suppression testing.
read more about liothyronine ...Liothyronine acts like endogenous T3, the biologically active thyroid hormone. It enters cell nuclei and binds thyroid hormone receptors, altering gene transcription involved in metabolism, growth, development, and cardiovascular function.
Liothyronine is used in adults and pediatric patients with qualifying hypothyroidism and in selected patients requiring thyroid-stimulating hormone suppression for well-differentiated thyroid cancer. It is also used in thyroid suppression testing. Uncorrected adrenal insufficiency is a contraindication.
Adults with hypothyroidism usually start at 25 mcg once daily and can increase by 25 mcg every one or two weeks. The usual maintenance dose is 25 mcg to 75 mcg once daily. Older adults and patients with underlying cardiac disease start at 5 mcg once daily and increase in 5 mcg steps.
Liothyronine carries a boxed warning that thyroid hormones are not used for obesity or weight loss. Excess dosing can cause serious or life-threatening cardiac toxicity, especially in older adults or patients with cardiovascular disease. Other concerns include worsening blood glucose control, reduced bone mineral density with overtreatment, and acute adrenal crisis in patients with uncorrected adrenal insufficiency.
Current labeling includes hypothyroidism, selected thyroid-stimulating hormone suppression in well-differentiated thyroid cancer, and thyroid suppression testing.
The recommended adult starting dose is 25 mcg once daily.
The usual maintenance dose is 25 mcg to 75 mcg once daily.
No. Liothyronine carries a boxed warning against use for obesity or weight loss.
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