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Liletta is a prescription levonorgestrel-releasing intrauterine system containing 52 mg of levonorgestrel. It is indicated for pregnancy prevention for up to eight years and for treatment of heavy menstrual bleeding for up to five years in patients who choose intrauterine contraception.
read more about liletta ...Liletta releases levonorgestrel mainly within the uterus. Its contraceptive actions include thickening cervical mucus, inhibiting sperm movement and function, and altering the endometrium. The exact mechanism responsible for reducing heavy menstrual bleeding is not fully established.
Liletta is used by patients seeking long-term intrauterine contraception and by patients with heavy menstrual bleeding who choose an intrauterine contraceptive. A trained healthcare professional inserts the device into the uterine cavity. Pregnancy, acute pelvic infection, certain uterine abnormalities, selected hormone-sensitive cancers, unexplained uterine bleeding, and acute liver disease are among the contraindications.
Liletta contains 52 mg of levonorgestrel and initially releases about 20 mcg per day, declining to about 6.5 mcg per day after eight years. For contraception, it is removed by the end of the eighth year. For continued treatment of heavy menstrual bleeding, it is replaced by the end of the fifth year.
Serious concerns include ectopic pregnancy or complications of an intrauterine pregnancy, sepsis, pelvic inflammatory disease or endometritis, uterine perforation, and partial or complete expulsion. Ovarian cysts and changes in bleeding patterns can occur. Liletta does not protect against HIV or other sexually transmitted infections.
Liletta is indicated for pregnancy prevention for up to eight years.
Liletta is indicated for treatment of heavy menstrual bleeding for up to five years in patients who choose intrauterine contraception.
Liletta contains 52 mg of levonorgestrel.
A trained healthcare professional inserts Liletta into the uterine cavity.
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Levonorgestrel. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Levonorgestrel. Date Accessed October 13, 2026.
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LILETTA Official Site. AbbVie and Medicines360. https://www.liletta.com/birth-control-comparison. Date Accessed October 13, 2026.
LILETTA (levonorgestrel-releasing intrauterine system) Prescribing Information. AbbVie and Medicines360. https://www.rxabbvie.com/pdf/liletta_pi.pdf. Date Accessed October 13, 2026.