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Levofloxacin is a prescription fluoroquinolone antibacterial. Current tablets contain 250 mg, 500 mg, or 750 mg. It treats selected infections caused by susceptible bacteria, including pneumonia, skin infections, chronic bacterial prostatitis, urinary tract infections, acute pyelonephritis, inhalational anthrax after exposure, and plague.
read more about levofloxacin ...Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase. Blocking these enzymes interferes with bacterial DNA replication, transcription, repair, and recombination, leading to death of susceptible bacteria.
Adults receive levofloxacin for labeled bacterial infections when the causative organism is susceptible. For acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated urinary tract infection, current labeling reserves levofloxacin for patients without suitable alternative treatment options. Pediatric use from age 6 months is limited to inhalational anthrax after exposure and plague.
Adults with creatinine clearance of at least 50 mL per minute receive 250 mg, 500 mg, or 750 mg once every 24 hours depending on the infection. Treatment length ranges from three to 60 days according to the indication. Creatinine clearance below 50 mL per minute requires dose adjustment.
Levofloxacin carries a boxed warning for disabling and potentially irreversible reactions including tendinitis and tendon rupture, peripheral neuropathy, and central nervous system effects. It can also worsen muscle weakness in myasthenia gravis. Other serious concerns include aortic aneurysm or dissection, severe glucose disturbances, QT prolongation, liver injury, hypersensitivity, and Clostridioides difficile-associated diarrhea.
Current labeling includes selected respiratory, skin, urinary, prostate, anthrax, and plague indications caused by susceptible bacteria.
Current levofloxacin tablets contain 250 mg, 500 mg, or 750 mg.
Yes. Adults with creatinine clearance below 50 mL per minute require an adjusted dosing regimen.
Yes. The boxed warning covers serious tendon, peripheral nerve, central nervous system, and myasthenia gravis risks.
DailyMed - LEVOFLOXACIN tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30958610-3803-45e6-aa3c-d256decbe6e4. Date Accessed October 12, 2026.
Levofloxacin. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548357/. Date Accessed October 12, 2026.
Levofloxacin. MedlinePlus. https://medlineplus.gov/druginfo/meds/a697040.html. Date Accessed October 12, 2026.
Levofloxacin. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Levofloxacin. Date Accessed October 12, 2026.
Levofloxacin. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK545180/. Date Accessed October 12, 2026.