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Levetiracetam is a prescription antiseizure medicine. Current immediate-release tablets and oral solution treat partial-onset seizures from age 1 month and are used as adjunctive therapy for myoclonic seizures from age 12 and primary generalized tonic-clonic seizures from age 6.
read more about levetiracetam ...The exact mechanism responsible for levetiracetam's antiseizure activity is not established. Levetiracetam binds to synaptic vesicle protein SV2A, a protein involved in neurotransmitter release, and this interaction is associated with its antiseizure effects.
Levetiracetam is used for partial-onset seizures in patients age 1 month and older. It is also used as adjunctive therapy for myoclonic seizures in patients age 12 and older with juvenile myoclonic epilepsy and for primary generalized tonic-clonic seizures in patients age 6 and older with idiopathic generalized epilepsy.
Adults age 16 and older usually start at 500 mg twice daily and can increase by 500 mg twice daily every two weeks to a recommended dose of 1500 mg twice daily. Pediatric dosing is weight-based and varies by age and seizure type. Adult kidney impairment requires dose adjustment according to creatinine clearance.
Serious concerns include behavioral abnormalities, psychotic symptoms, suicidal thoughts or behavior, somnolence, fatigue, anaphylaxis, angioedema, severe skin reactions, DRESS, coordination problems, and blood-cell abnormalities. Levetiracetam is withdrawn gradually to reduce the risk of increased seizure frequency or status epilepticus.
Current immediate-release labeling includes partial-onset, myoclonic, and primary generalized tonic-clonic seizures under age-specific criteria.
Adults age 16 and older usually start at 500 mg twice daily.
The recommended adult dose is 1500 mg twice daily for the labeled seizure types.
Yes. Adult dosing is adjusted according to creatinine clearance.
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Levetiracetam. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548785/. Date Accessed October 12, 2026.
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Levetiracetam. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Levetiracetam. Date Accessed October 12, 2026.
Levetiracetam. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK499890/. Date Accessed October 12, 2026.