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Leukeran is a prescription alkylating agent containing chlorambucil. Each tablet contains 2 mg. Current labeling includes chronic lymphocytic leukemia and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin disease.
read more about leukeran ...Chlorambucil is a nitrogen mustard alkylating agent that interferes with DNA replication and promotes apoptosis in susceptible cells. Its cytotoxic activity affects rapidly dividing malignant cells as well as normal bone marrow cells.
Leukeran is used for chronic lymphocytic leukemia and selected malignant lymphomas under current labeling. Blood counts are followed closely during therapy due to the risk of severe bone marrow suppression.
The usual oral dose is 0.1 mg to 0.2 mg per kg daily for three to six weeks, commonly about 4 mg to 10 mg per day in an average adult. Hodgkin disease commonly uses 0.2 mg per kg daily, while other lymphomas or chronic lymphocytic leukemia commonly use 0.1 mg per kg daily. Doses are adjusted according to blood counts and clinical response.
Leukeran carries a boxed warning for severe bone marrow suppression and states that chlorambucil is carcinogenic, probably mutagenic and teratogenic, and produces human infertility. Other serious concerns include secondary malignancies, seizures, severe skin reactions, and fetal harm.
Current labeling includes chronic lymphocytic leukemia and selected malignant lymphomas.
Each Leukeran tablet contains 2 mg of chlorambucil.
The usual initial dose is 0.1 mg to 0.2 mg per kg daily for three to six weeks.
Yes. The boxed warning states that chlorambucil can severely suppress bone marrow, is carcinogenic, is probably mutagenic and teratogenic, and produces human infertility.
Chlorambucil. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548207/. Date Accessed October 12, 2026.
Chlorambucil. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682899.html. Date Accessed October 12, 2026.
Chlorambucil. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/chlorambucil. Date Accessed October 12, 2026.
Chlorambucil. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Chlorambucil. Date Accessed October 12, 2026.
DailyMed - LEUKERAN (chlorambucil) tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=58a3c995-5ad6-465d-8437-5970c9088213&type=display. Date Accessed October 12, 2026.