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What Is Lantus?

Lantus is a prescription long-acting insulin containing insulin glargine. It is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. Lantus contains 100 units per mL and is supplied in a 10 mL vial and 3 mL SoloStar prefilled pens.

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What Is Lantus?

Lantus is a prescription long-acting insulin containing insulin glargine. It is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. Lantus contains 100 units per mL and is supplied in a 10 mL vial and 3 mL SoloStar prefilled pens.

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How Does Lantus Work?

Insulin glargine lowers blood glucose by increasing glucose uptake into skeletal muscle and fat and by reducing glucose production by the liver. After subcutaneous injection, it forms microprecipitates that release small amounts of insulin glargine over an extended period.

Who Is Treated With Lantus?

Lantus is used in adults and pediatric patients with diabetes mellitus who require basal insulin. In type 1 diabetes, Lantus is used with short-acting insulin. It is not recommended for treatment of diabetic ketoacidosis.

How Is Lantus Dosed?

Lantus is injected subcutaneously once daily at the same time each day. In insulin-naive adults with type 2 diabetes, the recommended starting dose is 0.2 units per kg or up to 10 units once daily. In type 1 diabetes, the starting dose is about one-third of the total daily insulin requirement, with the remainder supplied by short-acting mealtime insulin.

What Serious Risks Are Linked to Lantus?

Hypoglycemia is the most common serious risk of insulin therapy. Other concerns include severe hypersensitivity, hypokalemia, medication errors, lipodystrophy, localized cutaneous amyloidosis, and fluid retention or heart failure when used with peroxisome proliferator-activated receptor gamma agonists. Lantus is not mixed with other insulins or given intravenously.

Frequently Asked Questions About Lantus

What does Lantus treat?

Lantus improves glycemic control in adults and pediatric patients with diabetes mellitus.

How frequently is Lantus injected?

Lantus is injected subcutaneously once daily at the same time each day.

What is the starting dose for an insulin-naive adult with type 2 diabetes?

The recommended starting dose is 0.2 units per kg or up to 10 units once daily.

Can Lantus be mixed with another insulin?

No. Current labeling directs against diluting or mixing Lantus with another insulin or liquid.

References

DailyMed - LANTUS (insulin glargine) injection, solution. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d5e07a0c-7e14-4756-9152-9fea485d654a. Date Accessed October 8, 2026.

Insulin Glargine (rDNA origin) Injection. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a600027.html. Date Accessed October 8, 2026.

Insulin Glargine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Insulin-glargine. Date Accessed October 8, 2026.

Insulin. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK560688/. Date Accessed October 8, 2026.

LANTUS (insulin glargine) Prescribing Information. Sanofi. https://products.sanofi.us/lantus/lantus.pdf. Date Accessed October 8, 2026.