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Lamictal is a prescription antiseizure medicine containing lamotrigine. Current labeling includes adjunctive treatment of partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome from age 2. It also includes selected conversion to monotherapy for partial-onset seizures from age 16 and maintenance treatment of bipolar I disorder in adults.
read more about lamictal ...The exact mechanisms responsible for the antiseizure and bipolar maintenance effects are not established. Lamotrigine inhibits voltage-sensitive sodium channels in laboratory studies and reduces release of excitatory neurotransmitters such as glutamate.
Lamictal is used as adjunctive epilepsy therapy from age 2 for the labeled seizure types. Conversion to monotherapy is labeled from age 16 under specified prior antiseizure drug conditions. In adults with bipolar I disorder, Lamictal is used for maintenance after an acute mood episode has been treated with standard therapy. It is not recommended for acute mania or mixed episodes.
Lamictal dosing depends on the indication, age, and interacting medicines. In adults not taking valproate or enzyme-inducing antiseizure drugs, common titration begins at 25 mg once daily for two weeks and increases gradually. The usual bipolar I maintenance target is 200 mg daily in this group. Valproate requires lower starting and target doses, while enzyme-inducing medicines require higher regimens.
Lamictal carries a boxed warning for serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Risk rises with valproate, excessive starting doses, or rapid titration. Other serious concerns include hemophagocytic lymphohistiocytosis, DRESS and multiorgan failure, cardiac rhythm abnormalities in susceptible patients, blood dyscrasias, suicidal thoughts or behavior, aseptic meningitis, and withdrawal seizures.
Current labeling includes selected seizure disorders and maintenance treatment of bipolar I disorder.
Slow titration reduces the risk associated with serious lamotrigine skin reactions.
The usual target is 200 mg daily.
Yes. The boxed warning concerns serious and potentially life-threatening skin rashes.
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