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What Is Labetalol?

Labetalol hydrochloride is a prescription adrenergic blocker used to treat hypertension. Oral tablets have both selective alpha-1 adrenergic blocking activity and nonselective beta adrenergic blocking activity. Current products include 100 mg, 200 mg, and 300 mg tablets, with some labels also listing a 400 mg strength.

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What Is Labetalol?

Labetalol hydrochloride is a prescription adrenergic blocker used to treat hypertension. Oral tablets have both selective alpha-1 adrenergic blocking activity and nonselective beta adrenergic blocking activity. Current products include 100 mg, 200 mg, and 300 mg tablets, with some labels also listing a 400 mg strength.

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How Does Labetalol Lower Blood Pressure?

Labetalol blocks alpha-1 adrenergic receptors and beta adrenergic receptors. Alpha-1 blockade reduces peripheral vascular resistance, while beta blockade reduces adrenergic effects on the heart. Together these actions lower blood pressure.

Who Is Treated With Labetalol?

Oral labetalol is used for hypertension and can be used alone or with other antihypertensive medicines. Contraindications include bronchial asthma or obstructive airway disease, decompensated heart failure, greater than first-degree heart block, cardiogenic shock, severe bradycardia, and hypersensitivity to labetalol.

How Is Labetalol Dosed?

The recommended initial oral dose is 100 mg twice daily. The dose can increase by 100 mg twice daily at intervals of two to three days according to blood pressure response. The recommended maintenance range is 200 mg to 400 mg twice daily.

What Serious Risks Are Linked to Labetalol?

Serious concerns include symptomatic postural hypotension, syncope, severe bradycardia, heart block, cardiac arrest, and worsening heart failure. Abrupt discontinuation in patients with coronary artery disease can worsen angina and has been associated with myocardial infarction. Heart rate, rhythm, and blood pressure are monitored during treatment.

Frequently Asked Questions About Labetalol

What does labetalol treat?

Oral labetalol treats hypertension.

What is the usual starting dose?

The recommended initial dose is 100 mg twice daily.

What is the usual maintenance range?

The recommended maintenance range is 200 mg to 400 mg twice daily.

Why should labetalol not be stopped abruptly in coronary artery disease?

Sudden withdrawal of beta blockade can worsen angina and has been associated with myocardial infarction.

References

DailyMed - LABETALOL HYDROCHLORIDE tablet, film coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7f7fade-98a6-4741-bfb9-f1eb54ad4565. Date Accessed October 8, 2026.

Labetalol. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK547846/. Date Accessed October 8, 2026.

Labetalol. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a685034.html. Date Accessed October 8, 2026.

Labetalol. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Labetalol. Date Accessed October 8, 2026.

Labetalol. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK534787/. Date Accessed October 8, 2026.