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What Is Klor-Con?

Klor-Con is a prescription potassium chloride product used to treat or prevent hypokalemia with or without metabolic alkalosis when dietary potassium or reduction of a potassium-lowering medicine is insufficient. Current Klor-Con extended-release tablets include 8 mEq and 10 mEq strengths, while related Klor-Con M products include 10 mEq, 15 mEq, and 20 mEq strengths.

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What Is Klor-Con?

Klor-Con is a prescription potassium chloride product used to treat or prevent hypokalemia with or without metabolic alkalosis when dietary potassium or reduction of a potassium-lowering medicine is insufficient. Current Klor-Con extended-release tablets include 8 mEq and 10 mEq strengths, while related Klor-Con M products include 10 mEq, 15 mEq, and 20 mEq strengths.

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How Does Klor-Con Replace Potassium?

Potassium chloride supplies potassium and chloride ions needed for normal cellular function, nerve conduction, skeletal and smooth muscle contraction, and cardiac activity. Replacement restores depleted potassium stores.

Who Is Treated With Klor-Con?

Klor-Con is used for treatment or prevention of hypokalemia when oral potassium replacement is appropriate. If serum potassium is below 2.5 mEq per L, current labeling directs intravenous potassium instead of oral treatment. Concomitant use with triamterene or amiloride is contraindicated for the current extended-release tablet formulation.

How Is Klor-Con Dosed?

Current Klor-Con extended-release tablet labeling lists 40 mEq to 100 mEq daily in divided doses for treatment of hypokalemia, with no more than 40 mEq in one dose. Prevention typically uses 20 mEq daily. Tablets are taken with meals and a glass of water or other liquid rather than on an empty stomach.

What Serious Risks Are Linked to Klor-Con?

Excess potassium can cause severe or fatal hyperkalemia, especially when kidney function is impaired or potassium-retaining medicines are used. Solid potassium chloride products can cause gastrointestinal ulceration, narrowing, obstruction, bleeding, or perforation. Serum potassium is monitored and the dose is adjusted according to laboratory results.

Frequently Asked Questions About Klor-Con

What does Klor-Con treat?

Klor-Con treats or prevents hypokalemia with or without metabolic alkalosis under current labeling.

What is a typical treatment dose for hypokalemia?

Current extended-release tablet labeling lists 40 mEq to 100 mEq daily in divided doses.

What is a typical prevention dose?

The typical prevention dose is 20 mEq daily.

Should Klor-Con be taken on an empty stomach?

No. Current extended-release tablet labeling directs taking it with meals and a glass of water or other liquid.

References

DailyMed - KLOR-CON (potassium chloride) tablet, film coated, extended release. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4340c3f2-ecf8-44cd-9b69-217f543e24e2. Date Accessed October 8, 2026.

KLOR-CON 8 & 10 (Potassium Chloride Extended-Release Tablets, USP). Upsher-Smith Laboratories. https://www.upsher-smith.com/products/klor-con-8-10-potassium-chloride-extended-release-tablets-usp/. Date Accessed October 8, 2026.

KLOR-CON M10, M15, M20 (Potassium Chloride Extended-Release Tablets, USP). Upsher-Smith Laboratories. https://www.upsher-smith.com/products/klor-con-m10-m15-m20-potassium-chloride-extended-release-tablets-usp/. Date Accessed October 8, 2026.

Potassium. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a601099.html. Date Accessed October 8, 2026.

Potassium Chloride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Potassium-chloride. Date Accessed October 8, 2026.