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Ketorolac tromethamine is a prescription nonsteroidal anti-inflammatory drug used for short-term management of moderately severe acute pain requiring analgesia at the opioid level. Oral ketorolac is used only as continuation treatment after intravenous or intramuscular ketorolac in adults. Total combined treatment does not exceed five days.
read more about ketorolac ...Ketorolac inhibits cyclooxygenase activity and reduces prostaglandin synthesis. This produces analgesic and anti-inflammatory effects without acting as an opioid.
Ketorolac is used in adults for short-term moderately severe acute pain. Oral tablets are not approved as the initial dose and are not indicated for minor or chronic pain. Oral ketorolac is not approved for patients younger than 17.
Adults age 17 through 64 receive 20 mg once after intravenous or intramuscular treatment, then 10 mg every four to six hours as needed. Adults age 65 and older, patients with kidney impairment, or patients weighing less than 50 kg receive 10 mg once, then 10 mg every four to six hours as needed. Oral dosing does not exceed 40 mg per day.
Ketorolac carries boxed warnings for gastrointestinal bleeding, ulceration, and perforation, serious cardiovascular thrombotic events, kidney toxicity, bleeding risk, and restrictions related to labor and childbirth and coronary artery bypass graft surgery. It is contraindicated in advanced kidney impairment, active peptic ulcer disease, recent gastrointestinal bleeding, and patients at high risk of bleeding.
The combined duration of injection and oral treatment in adults does not exceed five days.
No. Oral ketorolac is used only as continuation treatment after intravenous or intramuscular ketorolac.
The maximum oral dose is 40 mg per day.
No. Current labeling limits ketorolac to short-term treatment of moderately severe acute pain.
A Randomized, Double-Blind Evaluation of Ketorolac Tromethamine for Postoperative Analgesia in Ambulatory Surgery Patients. https://pubmed.ncbi.nlm.nih.gov/8424573/. Date Accessed October 7, 2026.
Evaluation of Ketorolac, Ibuprofen, Acetaminophen, and an Acetaminophen-Codeine Combination in Postoperative Oral Surgery Pain. https://pubmed.ncbi.nlm.nih.gov/2082318/. Date Accessed October 7, 2026.
Ketorolac. https://www.ncbi.nlm.nih.gov/books/NBK548459/. Date Accessed October 7, 2026.
Ketorolac Tromethamine Tablets Prescribing Information. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=521b3d09-df08-fcae-e063-6294a90a6545. Date Accessed October 7, 2026.
Ketorolac: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a693001.html. Date Accessed October 7, 2026.