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Ketoconazole cream 2 percent is a prescription topical azole antifungal. Each gram contains 20 mg of ketoconazole. Current labeling includes selected fungal skin infections, cutaneous candidiasis, tinea versicolor, and seborrheic dermatitis.
read more about ketoconazole cream ...Ketoconazole inhibits fungal lanosterol 14-alpha-demethylase and reduces ergosterol synthesis. This disrupts normal fungal cell membrane structure and inhibits growth of susceptible dermatophytes and yeasts.
Ketoconazole cream 2 percent is used for tinea corporis, tinea cruris, and tinea pedis caused by susceptible dermatophytes, tinea versicolor caused by Malassezia furfur, cutaneous candidiasis, and seborrheic dermatitis. It is for topical dermatologic use and is not used in the eyes.
For cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis, and tinea versicolor, the cream is applied once daily to the affected area and surrounding skin. Candidiasis, tinea corporis, tinea cruris, and tinea versicolor usually use about two weeks of treatment, while tinea pedis uses six weeks. Seborrheic dermatitis uses application twice daily for four weeks or until clearing.
Local reactions include irritation, itching, stinging, burning, and contact dermatitis. Hypersensitivity to ketoconazole or formulation ingredients is a contraindication. Some formulations contain sulfites that can trigger allergic-type reactions in susceptible patients.
Current prescription cream contains ketoconazole 2 percent, equivalent to 20 mg per gram.
Current labeling includes selected tinea infections, tinea versicolor, cutaneous candidiasis, and seborrheic dermatitis.
Current labeling lists six weeks of treatment for tinea pedis.
It is applied to the affected area twice daily for four weeks or until clinical clearing.
A Double-Blind Trial of Treatment of Seborrhoeic Dermatitis With 2% Ketoconazole Cream Compared With 1% Hydrocortisone Cream. https://pubmed.ncbi.nlm.nih.gov/2529893/. Date Accessed October 7, 2026.
Double-Blind Treatment of Seborrheic Dermatitis With 2% Ketoconazole Cream. https://pubmed.ncbi.nlm.nih.gov/3159759/. Date Accessed October 7, 2026.
Ketoconazole 2% Cream Versus Hydrocortisone 1% Cream in the Treatment of Seborrheic Dermatitis. A Double-Blind Comparative Study. https://pubmed.ncbi.nlm.nih.gov/2973476/. Date Accessed October 7, 2026.
Ketoconazole Cream 2% Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cad7c647-34a9-4e4e-83b3-8d78e58f588f. Date Accessed October 7, 2026.
Ketoconazole Topical: MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a605014.html. Date Accessed October 7, 2026.