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Jentadueto XR is a prescription combination of linagliptin and extended-release metformin hydrochloride. It is used with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Current strengths contain either 5 mg of linagliptin with 1000 mg of metformin or 2.5 mg of linagliptin with 1000 mg of metformin.
read more about jentadueto xr ...Linagliptin inhibits DPP-4 and increases active incretin hormone concentrations, which increases glucose-dependent insulin release and decreases glucagon secretion. Metformin lowers hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity.
Jentadueto XR is used in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. It is not recommended for type 1 diabetes. Treatment is contraindicated when estimated glomerular filtration rate is below 30 mL per minute per 1.73 square meters, and initiation is not recommended when the rate is between 30 and 45.
Jentadueto XR is taken once daily with a meal. Patients not currently taking metformin usually start with 5 mg of linagliptin and 1000 mg of extended-release metformin once daily. The maximum daily dose is 5 mg of linagliptin and 2000 mg of metformin. Tablets are swallowed whole and are not split, crushed, dissolved, or chewed.
Jentadueto XR carries a boxed warning for metformin-associated lactic acidosis, which can be fatal. Other serious concerns include pancreatitis, low blood glucose when combined with insulin or insulin secretagogues, severe hypersensitivity, vitamin B12 deficiency, severe joint pain, bullous pemphigoid, and heart failure risk associated with the DPP-4 inhibitor class.
Jentadueto XR improves glycemic control in adults with type 2 diabetes mellitus when used with diet and exercise.
Jentadueto XR is taken once daily with a meal.
No. The extended-release tablets are swallowed whole and are not split, crushed, dissolved, or chewed.
Yes. The boxed warning concerns metformin-associated lactic acidosis.
Efficacy and Safety of Linagliptin Co-Administered With Low-Dose Metformin Once Daily Versus High-Dose Metformin Twice Daily in Treatment-Na?ve Patients With Type 2 Diabetes: A Double-Blind Randomized Trial. https://pubmed.ncbi.nlm.nih.gov/25805187/. Date Accessed October 6, 2026.
Initial Combination of Linagliptin and Metformin Improves Glycaemic Control in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Study. https://pubmed.ncbi.nlm.nih.gov/22356132/. Date Accessed October 6, 2026.
JENTADUETO XR (Linagliptin and Metformin Hydrochloride Extended-Release) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3d02a4d4-d312-80b4-05c4-691b8f0aa7aa. Date Accessed October 6, 2026.
Linagliptin: MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a611036.html. Date Accessed October 6, 2026.
Metformin: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a696005.html. Date Accessed October 6, 2026.