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Javadin is a prescription immediate-release oral liquid containing clonidine hydrochloride. It is indicated for treatment of hypertension in adults to lower blood pressure. The liquid contains 0.02 mg of clonidine hydrochloride per mL.
read more about javadin ...Clonidine stimulates alpha adrenergic receptors in the brain stem. This reduces sympathetic outflow from the central nervous system and decreases peripheral vascular resistance, renal vascular resistance, heart rate, and blood pressure.
Javadin is used in adults with hypertension and can be used alone or with other antihypertensive medicines. Safety and efficacy are not established in pediatric patients. Patients with kidney impairment can require a lower initial dose and closer monitoring.
The recommended initial dose is 0.1 mg by mouth twice daily, in the morning and at bedtime, with or without food. The daily dose can increase by 0.1 mg at weekly intervals according to response. Common therapeutic doses range from 0.2 mg to 0.6 mg daily in divided doses, and the maximum recommended daily dose is 2.4 mg.
Javadin can cause slow heart rate, cardiac conduction abnormalities, symptomatic low blood pressure, sedation, and somnolence. Abrupt discontinuation can cause rebound hypertension and has been associated with hypertensive encephalopathy, stroke, and death. Treatment is tapered gradually over two to four days when it is discontinued.
Javadin treats hypertension in adults.
The liquid contains 0.02 mg of clonidine hydrochloride per mL.
The recommended initial dose is 0.1 mg twice daily.
Sudden clonidine withdrawal can cause rebound hypertension, so the dose is reduced gradually when treatment ends.
Clonidine: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a682243.html. Date Accessed October 6, 2026.
Clonidine. https://www.ncbi.nlm.nih.gov/books/NBK459124/. Date Accessed October 6, 2026.
JAVADIN (Clonidine Hydrochloride) Oral Solution. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c36d94f5-a30d-4997-b141-e79a4ea45ecf. Date Accessed October 6, 2026.
Javadin (Clonidine Hydrochloride) Oral Solution Approval Letter. https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2025/220256Orig1s000ltr.pdf. Date Accessed October 6, 2026.
Low-Dose Clonidine Administration in the Treatment of Mild or Moderate Essential Hypertension: Results From a Double-Blind Placebo-Controlled Study. https://pubmed.ncbi.nlm.nih.gov/2165088/. Date Accessed October 6, 2026.