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Janumet XR is a prescription combination of sitagliptin and extended-release metformin hydrochloride. It is used with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Current strengths include 50 mg and 500 mg, 50 mg and 1000 mg, and 100 mg and 1000 mg.
read more about janumet xr ...Sitagliptin inhibits DPP-4 and increases active incretin hormone concentrations, which increases glucose-dependent insulin release and reduces glucagon secretion. Metformin lowers hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity.
Janumet XR is used in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. It is not used for type 1 diabetes. Current labeling states that Janumet XR has not been studied in patients with a history of pancreatitis.
Janumet XR is taken once daily with a meal. Patients not currently taking metformin usually start with 100 mg of sitagliptin and 1000 mg of extended-release metformin once daily. The maximum daily dose is 100 mg of sitagliptin and 2000 mg of metformin. Tablets are swallowed whole and are not split, crushed, or chewed.
Janumet XR carries a boxed warning for metformin-associated lactic acidosis, which can be fatal. Other serious concerns include pancreatitis, heart failure risk associated with the DPP-4 inhibitor class, acute kidney failure, vitamin B12 deficiency, severe hypersensitivity, severe joint pain, bullous pemphigoid, and low blood glucose when combined with insulin or an insulin secretagogue.
Janumet XR is used with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Janumet XR is taken once daily with a meal.
No. The extended-release tablets are swallowed whole and are not split, crushed, or chewed.
Yes. The boxed warning concerns metformin-associated lactic acidosis.
Bioequivalence of Sitagliptin/Metformin Fixed-Dose Combination Tablets and Concomitant Administration of Sitagliptin and Metformin in Healthy Adult Subjects: A Randomized, Open-Label, Crossover Study. https://pubmed.ncbi.nlm.nih.gov/20923244/. Date Accessed October 6, 2026.
Effect of Initial Combination Therapy With Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, and Metformin on Glycemic Control in Patients With Type 2 Diabetes. https://pubmed.ncbi.nlm.nih.gov/17485570/. Date Accessed October 6, 2026.
JANUMET XR (Sitagliptin and Metformin Hydrochloride Extended-Release) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50. Date Accessed October 6, 2026.
Metformin: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a696005.html. Date Accessed October 6, 2026.
Sitagliptin: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a606023.html. Date Accessed October 6, 2026.