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Isosorbide appears in the names of organic nitrate medicines including isosorbide mononitrate and isosorbide dinitrate. This page focuses on current isosorbide mononitrate extended-release tablets used to prevent angina pectoris due to coronary artery disease. Current extended-release strengths include 30 mg, 60 mg, and 120 mg.
read more about isosorbide ...Isosorbide mononitrate is an organic nitrate that relaxes vascular smooth muscle and dilates veins and arteries. Venous dilation reduces cardiac preload and myocardial oxygen demand, which helps prevent angina.
Extended-release isosorbide mononitrate is used to prevent angina pectoris caused by coronary artery disease. Its onset is not rapid enough to stop an acute angina attack after symptoms begin. Isosorbide dinitrate is a separate nitrate medicine with its own dosing instructions.
The recommended starting dose is 30 mg or 60 mg once daily in the morning. After several days, the dose can increase to 120 mg once daily. A 240 mg daily dose is used rarely. Extended-release tablets are swallowed with fluid and are not chewed or crushed.
Isosorbide mononitrate can cause severe low blood pressure, dizziness, fainting, and headache. Sildenafil can markedly increase its blood pressure lowering effect and cause severe hypotension. Methemoglobinemia has also been reported with organic nitrate exposure.
It is used to prevent angina caused by coronary artery disease.
The recommended starting dose is 30 mg or 60 mg once daily in the morning.
No. Its onset is not rapid enough to stop an attack after it begins.
No. The combination can produce severe low blood pressure.
Efficacy and Safety of Extended-Release Isosorbide Mononitrate for Stable Effort Angina Pectoris. https://pubmed.ncbi.nlm.nih.gov/8256699/. Date Accessed October 5, 2026.
Isosorbide. https://www.ncbi.nlm.nih.gov/books/NBK557839/. Date Accessed October 5, 2026.
Isosorbide: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a682348.html. Date Accessed October 5, 2026.
Isosorbide Mononitrate Extended-Release Tablets Prescribing Information. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a1e317a-7b05-4d30-9bbc-1d4ccd56ba3c. Date Accessed October 5, 2026.
Nitrates. https://www.ncbi.nlm.nih.gov/books/NBK545149/. Date Accessed October 5, 2026.