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Isosorbide mononitrate is a prescription organic nitrate and the major active metabolite of isosorbide dinitrate. Current extended-release tablets contain 30 mg, 60 mg, or 120 mg. They are indicated for prevention of angina pectoris due to coronary artery disease.
read more about isosorbide mononitrate ...Isosorbide mononitrate relaxes vascular smooth muscle and dilates veins and arteries. Venous dilation reduces cardiac preload and myocardial oxygen demand, which contributes to its antianginal action.
Extended-release isosorbide mononitrate is used to prevent angina caused by coronary artery disease. Its onset is not rapid enough to stop an acute angina episode. Safety and efficacy in pediatric patients are not established.
The recommended starting dose is 30 mg or 60 mg once daily in the morning. After several days, the dose can increase to 120 mg once daily. A 240 mg daily dose is used rarely. Extended-release tablets are swallowed with fluid and are not chewed or crushed.
Isosorbide mononitrate can cause severe low blood pressure, dizziness, fainting, and headache. Sildenafil can markedly increase its blood pressure lowering effect and cause severe hypotension. Methemoglobinemia has also been reported with organic nitrate exposure.
Extended-release tablets are used to prevent angina caused by coronary artery disease.
The recommended starting dose is 30 mg or 60 mg once daily in the morning.
Yes. After several days, the dose can increase to 120 mg once daily.
No. Its onset is not rapid enough to stop an acute angina episode.
Isosorbide: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a682348.html. Date Accessed October 5, 2026.
Isosorbide. https://www.ncbi.nlm.nih.gov/books/NBK557839/. Date Accessed October 5, 2026.
Isosorbide Mononitrate Extended-Release Tablets Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=cd953cfa-b6f5-4b82-afcc-52a57236b9d3. Date Accessed October 5, 2026.
Isosorbide Mononitrate Tablets Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?audience=professional&setid=0d739bf3-0672-4504-9064-b39d6b200b47. Date Accessed October 5, 2026.
Nitrates. https://www.ncbi.nlm.nih.gov/books/NBK545149/. Date Accessed October 5, 2026.