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Indomethacin is a prescription nonsteroidal anti-inflammatory drug. Current immediate-release capsules contain 25 mg or 50 mg. They are used for selected inflammatory joint disorders, acute painful shoulder, and acute gouty arthritis.
read more about indomethacin ...Indomethacin inhibits cyclooxygenase enzymes and reduces prostaglandin synthesis. This action decreases inflammation, pain, and fever associated with susceptible conditions.
Current capsule labeling includes moderate to severe rheumatoid arthritis with acute flares, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, acute painful shoulder from bursitis or tendinitis, and acute gouty arthritis.
Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis start at 25 mg two or three times daily. Acute painful shoulder uses 75 mg to 150 mg daily in three or four divided doses. Acute gouty arthritis uses 50 mg three times daily. Arthritis dosing can increase gradually based on response and tolerability.
Indomethacin carries boxed warnings for heart attack, stroke, gastrointestinal bleeding, ulceration, and perforation. Other serious concerns include kidney injury, liver toxicity, high blood pressure, heart failure, anaphylactic reactions, severe skin reactions, anemia, and fetal toxicity. Use during coronary artery bypass graft surgery is contraindicated.
They treat selected forms of arthritis, acute painful shoulder, and acute gouty arthritis.
Current immediate-release capsules contain 25 mg or 50 mg of indomethacin.
The labeled starting dose is 25 mg two or three times daily.
The labeled dose is 50 mg three times daily.
DailyMed - INDOMETHACIN capsule. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=009097a5-2c1e-4f5d-8054-896cf896cb3d. Date Accessed October 2, 2026.
FDA Drug Safety Communication - FDA Strengthens Warning That Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Can Cause Heart Attacks or Strokes. https://www.fda.gov/media/92768/download. Date Accessed October 2, 2026.
Indomethacin - MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a681027.html. Date Accessed October 2, 2026.
Indomethacin - PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Indomethacin. Date Accessed October 2, 2026.
Indomethacin - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK555936/. Date Accessed October 2, 2026.