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Indocin is a prescription nonsteroidal anti-inflammatory drug containing indomethacin. Current branded U.S. forms include an oral suspension containing 25 mg per 5 mL and a 50 mg rectal suppository. Both forms are used under indication-specific dosing for inflammatory and painful conditions.
read more about indocin ...Indomethacin inhibits cyclooxygenase activity and decreases prostaglandin synthesis. Reduced prostaglandin production contributes to its anti-inflammatory, pain-relieving, and fever-reducing actions.
Current Indocin labeling includes moderate to severe rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute painful shoulder due to bursitis or tendinitis, and acute gouty arthritis. Treatment uses the lowest dose needed for the shortest duration consistent with the clinical goal.
Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis start at 25 mg two or three times daily. Acute painful shoulder uses 75 mg to 150 mg daily in three or four divided doses. Acute gouty arthritis uses 50 mg three times daily. The oral suspension contains 25 mg in each 5 mL.
Indocin carries boxed warnings for serious cardiovascular thrombotic events and gastrointestinal bleeding, ulceration, and perforation. Other concerns include high blood pressure, heart failure, kidney injury, liver toxicity, severe skin reactions, anemia, and fetal toxicity. Use during coronary artery bypass graft surgery is contraindicated.
Indocin contains indomethacin, a nonsteroidal anti-inflammatory drug.
Current branded forms include 25 mg per 5 mL oral suspension and 50 mg rectal suppositories.
The labeled dose is 50 mg three times daily until the acute attack subsides.
Yes. The boxed warnings concern serious cardiovascular thrombotic events and gastrointestinal bleeding, ulceration, and perforation.
DailyMed - INDOCIN - indomethacin suspension. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=73878376-1d24-423b-9f37-3666e83c95da. Date Accessed October 2, 2026.
Indomethacin - MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a681027.html. Date Accessed October 2, 2026.
Indomethacin - PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Indomethacin. Date Accessed October 2, 2026.
Indomethacin - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK555936/. Date Accessed October 2, 2026.
Indomethacin Rectal - MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a621040.html. Date Accessed October 2, 2026.