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What Is Indapamide?

Indapamide is a prescription oral antihypertensive and diuretic. It is chemically distinct from thiazide diuretics but has similar diuretic actions. Current tablets include 1.25 mg and 2.5 mg strengths.

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What Is Indapamide?

Indapamide is a prescription oral antihypertensive and diuretic. It is chemically distinct from thiazide diuretics but has similar diuretic actions. Current tablets include 1.25 mg and 2.5 mg strengths.

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How Does Indapamide Work?

Indapamide increases urinary sodium and water excretion and reduces peripheral vascular resistance. Its diuretic and vascular actions contribute to blood pressure reduction. Potassium loss increases as the dose rises.

Who Is Treated With Indapamide?

Indapamide is indicated for hypertension as monotherapy or with other antihypertensive medicines. It is also indicated for salt and fluid retention associated with congestive heart failure. Anuria and hypersensitivity to indapamide or other sulfonamide-derived drugs are contraindications.

How Is Indapamide Dosed?

Hypertension treatment starts at 1.25 mg once daily in the morning. The dose can increase to 2.5 mg after four weeks and then to 5 mg after another four weeks if needed. Heart failure edema starts at 2.5 mg each morning and can increase to 5 mg after one week.

What Serious Risks Are Linked to Indapamide?

Indapamide can cause severe low sodium and low potassium, particularly at higher doses. Other concerns include fluid and electrolyte imbalance, increased uric acid, changes in blood glucose, kidney dysfunction, photosensitivity, blood-cell disorders, and acute myopia or angle-closure glaucoma. Serum electrolytes are checked periodically during treatment.

Frequently Asked Questions About Indapamide

What conditions does indapamide treat?

Indapamide treats hypertension and salt and fluid retention associated with congestive heart failure.

What is the starting dose for hypertension?

The adult starting dose is 1.25 mg once daily in the morning.

What is the starting dose for heart failure edema?

The adult starting dose is 2.5 mg once daily in the morning.

Can indapamide lower sodium and potassium?

Yes. Hyponatremia and hypokalemia are recognized risks, and electrolyte monitoring is part of treatment.

References

Clinical Efficacy and Safety of Lower-Dose Indapamide Therapy in the Treatment of Patients With Mild to Moderate Hypertension. https://pubmed.ncbi.nlm.nih.gov/11835068/. Date Accessed October 2, 2026.

DailyMed - INDAPAMIDE tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=59cd3331-7afe-432a-8b50-39533fd5f392. Date Accessed October 2, 2026.

Double-Blind Comparison of Indapamide With a Placebo in Hypertensive Patients Treated by Practicing Physicians. https://pubmed.ncbi.nlm.nih.gov/3899418/. Date Accessed October 2, 2026.

Indapamide - MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a684062.html. Date Accessed October 2, 2026.

Indapamide - Medical Subject Headings. https://www.ncbi.nlm.nih.gov/mesh/68007190. Date Accessed October 2, 2026.