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Imodium A-D is an over-the-counter antidiarrheal containing loperamide hydrochloride 2 mg per caplet. It is labeled to control symptoms of diarrhea, including travelers' diarrhea. Current branded caplets use age- and weight-based directions.
read more about imodium ad ...Loperamide binds to opioid receptors in the intestinal wall and reduces release of acetylcholine and prostaglandins. This slows propulsive intestinal movement, increases intestinal transit time, and reduces loss of fluid and electrolytes in stool.
Current branded caplet labeling includes dosing directions for adults and children age 6 and older, with weight used when possible. Children age 2 through 5 require medical guidance, and children younger than 2 do not use the product. People with bloody or black stool do not use Imodium A-D.
Adults and children age 12 and older take two 2 mg caplets after the first loose stool, followed by one caplet after each later loose stool, with no more than four caplets in 24 hours. Children age 9 through 11 have a maximum of three caplets daily, while children age 6 through 8 have a maximum of two caplets daily under the labeled weight ranges.
Taking more loperamide than directed can cause serious heart rhythm problems or death. A doctor is consulted before use when fever, mucus in the stool, liver disease, or a history of abnormal heart rhythm is present. Treatment stops and medical advice is sought if symptoms worsen, diarrhea lasts longer than two days, or abdominal swelling develops.
Each current branded caplet contains 2 mg of loperamide hydrochloride.
Adults and children age 12 and older take two caplets after the first loose stool.
The current OTC label limits adults and children age 12 and older to four caplets in 24 hours.
Current labeling directs users to stop and seek medical advice if symptoms worsen, diarrhea continues beyond two days, or abdominal swelling or bulging develops.
DailyMed - IMODIUM A-D - loperamide hydrochloride tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=01da76d0-1979-4c45-9d39-c72ae4e4ffe2. Date Accessed October 2, 2026.
FDA Drug Safety Communication - Serious Heart Problems With High Doses of Loperamide. https://www.fda.gov/media/98335/download. Date Accessed October 2, 2026.
Loperamide - MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a682280.html. Date Accessed October 2, 2026.
Loperamide - PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Loperamide. Date Accessed October 2, 2026.
Loperamide - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557885/. Date Accessed October 2, 2026.