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Imiquimod cream 5 percent is a prescription topical immune response modifier. Current labeling includes selected actinic keratoses, biopsy-confirmed primary superficial basal cell carcinoma, and external genital or perianal warts under indication-specific criteria. Each single-use packet contains 250 mg of cream equivalent to 12.5 mg of imiquimod.
read more about imiquimod ...The exact therapeutic mechanism of imiquimod cream is not established. Treatment changes local immune activity and is associated with increased expression of inflammatory cytokines and immune-cell activity at treated sites.
Imiquimod 5 percent treats selected actinic keratoses on the face or scalp and selected superficial basal cell carcinomas in immunocompetent adults. It also treats external genital and perianal warts in immunocompetent patients age 12 and older.
Actinic keratosis treatment uses application twice weekly for 16 weeks. Superficial basal cell carcinoma treatment uses application five times weekly for six weeks. External genital or perianal warts are treated three times weekly until clearance or for a maximum of 16 weeks.
Imiquimod can cause intense local inflammatory reactions including erosion, swelling, weeping, and ulceration. Other concerns include persistent localized loss of skin pigment, flu-like systemic reactions, severe vulvar swelling with urinary retention, and reactions related to ultraviolet exposure. The cream is not used orally, in the eyes, or inside the vagina.
Current labeling includes selected actinic keratoses, superficial basal cell carcinoma, and external genital or perianal warts.
The cream is applied twice weekly for a full 16 weeks.
The cream is applied five times weekly for six weeks under the labeled criteria.
Yes. Intense redness, swelling, erosion, weeping, and ulceration can occur at the treatment site.
DailyMed - IMIQUIMOD cream 5 percent. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=59af8153-4cf8-4f22-9000-f239798d52d1&version=11. Date Accessed October 2, 2026.
Imiquimod Topical - MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a698010.html. Date Accessed October 2, 2026.
Imiquimod - National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/imiquimod. Date Accessed October 2, 2026.
Imiquimod - PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Imiquimod. Date Accessed October 2, 2026.
Imiquimod - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557413/. Date Accessed October 2, 2026.