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Imipramine hydrochloride is a prescription tricyclic antidepressant. Current tablet labeling includes relief of depression symptoms and temporary adjunctive treatment of childhood enuresis in children age 6 and older after possible organic causes have been excluded. Tablets are available in 10 mg, 25 mg, and 50 mg strengths.
read more about imipramine ...The exact antidepressant mechanism is not established. Its clinical activity is thought to involve increased adrenergic signaling through inhibition of norepinephrine uptake at nerve endings. Its action in childhood enuresis is considered separate from its antidepressant activity.
Imipramine is used for depression in adults and selected older adolescents under individualized dosing. It also has a temporary adjunctive role in reducing nighttime enuresis in children age 6 and older after organic causes have been excluded.
Adult outpatients with depression commonly start at 75 mg daily and can increase to 150 mg daily. Hospitalized adults can start at 100 mg daily in divided doses and increase according to response. Childhood enuresis starts at 25 mg daily, generally given one hour before bedtime, with age-based increases when needed.
Imipramine carries a boxed warning for increased suicidal thoughts and behavior in children, adolescents, and young adults taking antidepressants. Other concerns include heart rhythm abnormalities, seizures, low blood pressure, anticholinergic effects, blood-cell disorders, and toxicity in overdose. Monoamine oxidase inhibitor use and the acute recovery period after myocardial infarction are contraindications.
Current labeling includes depression and temporary adjunctive treatment of childhood enuresis from age 6.
A usual starting dose is 75 mg daily with gradual adjustment according to response.
The labeled starting dose is 25 mg daily in children age 6 and older.
Yes. The boxed warning concerns increased suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants.
DailyMed - IMIPRAMINE HYDROCHLORIDE tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d9dbcebe-9aba-4a93-a7b7-48d29e07d3c4. Date Accessed October 2, 2026.
Depression Medicines - U.S. Food and Drug Administration. https://www.fda.gov/consumers/womens-health-topics/depression-medicines. Date Accessed October 2, 2026.
Imipramine - MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a682389.html. Date Accessed October 2, 2026.
Imipramine - PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Imipramine. Date Accessed October 2, 2026.
Imipramine - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557656/. Date Accessed October 2, 2026.