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Hyzaar is a prescription fixed-dose combination containing losartan potassium and hydrochlorothiazide. Losartan is an angiotensin II receptor blocker and hydrochlorothiazide is a thiazide diuretic. Current tablet strengths are 50 mg/12.5 mg, 100 mg/12.5 mg, and 100 mg/25 mg.
read more about hyzaar ...Losartan blocks angiotensin II at the AT1 receptor and reduces vasoconstriction and aldosterone-related effects. Hydrochlorothiazide reduces sodium and chloride reabsorption in the distal renal tubule and increases urinary sodium and water excretion. Their combined actions lower blood pressure.
Hyzaar treats hypertension in adults and is also indicated to reduce stroke risk in patients with hypertension and left ventricular hypertrophy. Current labeling states that the stroke-risk reduction shown in the supporting study did not apply to Black patients.
The usual starting dose for hypertension is 50 mg losartan with 12.5 mg hydrochlorothiazide once daily. The dose can increase after about three weeks to a maximum of 100 mg/25 mg once daily. Hyzaar can be taken with or without food.
Hyzaar carries a boxed warning for fetal toxicity and is stopped when pregnancy is detected. Other serious concerns include low blood pressure, impaired kidney function, potassium and other electrolyte abnormalities, acute angle-closure glaucoma, high uric acid, systemic lupus erythematosus exacerbation, and nonmelanoma skin cancer linked to hydrochlorothiazide exposure.
Hyzaar treats hypertension and reduces stroke risk in selected patients with hypertension and left ventricular hypertrophy.
The usual starting dose is 50 mg losartan with 12.5 mg hydrochlorothiazide once daily.
The maximum labeled dose is 100 mg losartan with 25 mg hydrochlorothiazide once daily.
Yes. The boxed warning concerns fetal toxicity.
Angiotensin Receptor Blockers and HCTZ Combination Drugs. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK606100/. Date Accessed October 1, 2026.
DailyMed - HYZAAR (losartan potassium and hydrochlorothiazide) tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4116ccde-2e23-45f4-b12f-6337df877744. Date Accessed October 1, 2026.
Hyzaar. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/9940097. Date Accessed October 1, 2026.
Losartan. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a695008.html. Date Accessed October 1, 2026.
Losartan Potassium and Hydrochlorothiazide. DailyMed. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1d6712a3-bfb3-4081-b8f6-6057eb4baa27. Date Accessed October 1, 2026.