Provide a valuable resource to your clients or customers by linking to this resource page. Just place the following link on your website.
Hydroxyzine hydrochloride is a prescription medicine with antihistaminic and sedating effects. Current tablet labeling includes symptomatic relief of anxiety and tension, management of itching from allergic conditions, and sedation before or after general anesthesia. Tablets are available in 10 mg, 25 mg, and 50 mg strengths.
read more about hydroxyzine ...The exact mechanism behind all hydroxyzine effects is not fully defined. Current labeling describes suppression of activity in selected subcortical regions of the central nervous system and confirms antihistaminic, skeletal muscle relaxing, bronchodilator, analgesic, and antiemetic activity.
Hydroxyzine hydrochloride is used for anxiety and tension associated with psychoneurosis, itching from allergic conditions such as chronic urticaria and atopic or contact dermatoses, and sedation around general anesthesia. Long-term antianxiety use beyond four months has not been assessed in systematic clinical studies.
For adult anxiety, current labeling lists 50 mg to 100 mg four times daily. Adult itching uses 25 mg three or four times daily. Sedation before or after general anesthesia uses 50 mg to 100 mg in adults. Pediatric doses vary by age, weight, and indication.
Hydroxyzine can cause drowsiness and can intensify the effects of alcohol, opioids, barbiturates, and other central nervous system depressants. QT prolongation and torsades de pointes have been reported. A prolonged QT interval, early pregnancy, and hypersensitivity to hydroxyzine or related cetirizine compounds are contraindications under current labeling.
Current labeling includes anxiety and tension, allergic itching, and sedation around general anesthesia.
The labeled adult dose for pruritus is 25 mg three or four times daily.
Yes. Drowsiness can occur, and alcohol or other central nervous system depressants can intensify this effect.
Yes. QT prolongation and torsades de pointes have been reported during hydroxyzine use.
DailyMed - HYDROXYZINE HYDROCHLORIDE tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7534a3bb-b4cd-415f-8612-53b37dc6d55f. Date Accessed October 1, 2026.
Hydroxyzine. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548128/. Date Accessed October 1, 2026.
Hydroxyzine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682866.html. Date Accessed October 1, 2026.
Hydroxyzine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyzine. Date Accessed October 1, 2026.
Hydroxyzine Hydrochloride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyzine-Hydrochloride. Date Accessed October 1, 2026.